Effect of adherence to European treatment recommendations on early arthritis outcome: data from the ESPOIR cohort

Annals of the Rheumatic Diseases
Cécile EscalasPhilippe Ravaud

Abstract

To assess the association of adherence to the 2007 recommendations of the European League Against Rheumatism (EULAR) for managing early arthritis and radiographic progression and disability in patients The authors conducted a prospective population-based cohort study. The ESPOIR cohort was a French cohort of 813 patients with early arthritis not receiving disease-modifying antirheumatic drugs (DMARDs). Adherence to the 2007 EULAR recommendations was defined by measuring adherence to three of the recommendations concerning the initiation and early adjustment of DMARDs. The study endpoints were radiographic progression, defined as the presence of at least one new erosion between baseline and 1 year, and disability as a heath assessment questionnaire score ≥1 at 2 years. A propensity score of being treated according to the recommendations was developed. After adjustment for propensity score, treatment centre and the main confounding factors, patients without recommendation adherence were at increased risk of radiographic progression at 1 year, and of functional impairment at 2 years (OR 1.98, (95% CI: 1.08 to 3.62 and OR: 2.36, (95% CI: 1.17 to 4.67), respectively). Early arthritis patients whose treatment adhered to the 2007 EULA...Continue Reading

Citations

Dec 25, 2015·Best Practice & Research. Clinical Rheumatology·Sehrash MahmoodRobert Landewé
Mar 20, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Thomas KramsArnaud Constantin
Jul 6, 2014·Joint, Bone, Spine : Revue Du Rhumatisme·Cécile Gaujoux-VialaUNKNOWN French Society for Rheumatology
Jun 17, 2015·Nature Reviews. Rheumatology·Rachelle BuchbinderIan A Harris
Sep 1, 2015·Rheumatology·Alexandra N Colebatch-BournChristopher J Edwards
Sep 23, 2014·Joint, Bone, Spine : Revue Du Rhumatisme·Bernard Combe, Nathalie Rincheval
Sep 11, 2019·Journal of Clinical Medicine·Bogdan BatkoZbigniew Żuber
Jun 7, 2019·RMD Open·Sytske Anne BergstraRobert Landewé

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