Effect of adipose tissue volume on prognosis in patients with non-small cell lung cancer

Clinical Imaging
Jeong Won LeeSang Mi Lee

Abstract

This study evaluated the relationship between adipose tissue volume and survival in patients with non-small cell lung cancer (NSCLC). We retrospectively included 171 NSCLC patients who underwent staging 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and subsequent curative surgical resection or definite chemoradiotherapy. Maximum standardized uptake value (SUV) of lung cancer normalized by lean body mass (SULmax) and volume and mean SUV of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were derived from PET/CT images. The relationships of volume and mean SUV of SAT and VAT with survival were assessed. Of the 171 patients, 79 (46.2%) experienced disease progression and 61 patients (35.7%) died during follow-up. SULmax had significant negative correlation with SAT volume (p = 0.003), but not with VAT volume and mean SUV of SAT and VAT (p > 0.05). On multivariate analysis, advanced TNM stage and high SULmax were significantly related with worse progression-free survival (PFS) and high SAT volume was significantly associated with better PFS (p < 0.05). Patient subgroups of high SULmax (>4.6) and low SAT volume (<75 cm3) had the highest disease progression rate of 61.7%, w...Continue Reading

Citations

Sep 6, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Jeong Won LeeSang Mi Lee
Jul 4, 2019·Journal of Thoracic Imaging·Amelie S TroschelFlorian J Fintelmann
Oct 27, 2020·Current Opinion in Supportive and Palliative Care·Tanvir AbbassDonald C McMillan
Dec 12, 2020·Clinical Lung Cancer·Maria Cristina MeleEmilio Bria
Sep 25, 2021·EJNMMI Research·Jessie HanDimitrios C Karampinos

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