Effect of Adjunctive Estradiol on Schizophrenia Among Women of Childbearing Age: A Randomized Clinical Trial.

JAMA Psychiatry
Mark WeiserJohn M Davis

Abstract

Several lines of evidence suggest that estradiol influences the course of schizophrenia, and a previous randomized controlled trial demonstrated that transdermal estradiol improved symptoms in female patients of childbearing age. However, many initial positive findings in schizophrenia research are not later replicated. To independently replicate the results of the effect of estradiol on schizophrenia in women of childbearing age. An 8-week randomized, placebo-controlled trial performed in the Republic of Moldova between December 4, 2015, and July 29, 2016, among 200 premenopausal women aged 19 to 46 years with schizophrenia or schizoaffective disorder as defined by the DSM-5. Patients were randomized to receive a 200-μg estradiol patch or placebo patch changed twice a week added to their antipsychotic treatment. The primary outcome was the positive subscale of the Positive and Negative Syndrome Scale (PANSS; lower scores indicated fewer symptoms and higher scores indicated more symptoms), analyzed with mixed models for repeated measures on an intention-to-treat basis. A total of 100 women (median age, 38 years; interquartile range, 34-42 years) were randomized to receive an estradiol patch and 100 women (median age, 38 years; ...Continue Reading

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Citations

Aug 1, 2019·JAMA Psychiatry·Dost Ongür
Feb 19, 2020·Translational Psychiatry·Filippo ErliDeepak P Srivastava
Feb 10, 2021·Current Opinion in Psychiatry·Bodyl A BrandIris E C Sommer

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