Effect of administration of a novel recombinant bovine interferon on length of oestrous cycle in cattle.

Research in Veterinary Science
E C BleachD Savva

Abstract

In ruminants, extensive reproductive loss occurs during the process of maternal recognition of pregnancy and it has been suggested that trophoblast interferons may be potential therapeutic agents. This paper reports results from a trial using eight first lactation Holstein-Friesian heifers to test the efficacy of a novel recombinant bovine interferon produced in bacteria in extending the life of the corpus luteum. Oestrus was synchronised in these animals and 0.1 mg of this non-glycosylated interferon was infused into the uterus twice daily for 13 days starting approximately 12 days after oestrus. This treatment resulted in an extension of the lifespan of the corpus luteum by 5.5 days (P=0.028) compared with untreated controls. In these animals the interovulatory period was extended by 6.4 days (P=0.009). Administration of this protein did not have any adverse effects either on body temperature or on daily milk yields. The results indicate that this novel interferon may have potential therapeutic application for reducing embryo mortality.

References

Nov 1, 1978·Journal of Reproduction and Fertility·N Ayalon
Apr 1, 1985·Biology of Reproduction·F F BartolW W Thatcher
Jun 23, 1984·The Veterinary Record·D L Frape, J D Pringle
May 15, 1996·Annals of the New York Academy of Sciences·T S GrewalD Savva

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Citations

Aug 24, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·O BouéM Rodríguez
Apr 27, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J B Barreto FilhoR R Golgher
May 31, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Toru TakahashiKazuyoshi Hashizume

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