PMID: 9193927May 1, 1997Paper

Effect of administration of malathion for 14 days on macrophage function and mast cell degranulation

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
K E Rodgers, S Xiong

Abstract

Previous studies have shown that acute, oral administration of malathion modulated the humoral immune response to T-cell-dependent antigen, mitogenic responses, macrophage function, and mast cell degranulation. While administration of malathion for 14 days did not affect the generation of an immune response to antigen, it was possible that macrophage and mast cell functions were affected. In this report, the effect of malathion administration for 14 days upon these parameters were assessed. This treatment regimen increased the respiratory burst capacity to a maximal level at a dose of 1 mg/kg/day or greater. The effect of oral administration of malathion for 14 days on the degranulation of mast cells in various organs (heart, skin, and small intestine) and peritoneal lavage fluid was also assessed. At doses of 1 mg/kg/day and above, the number of mast cells that was undegranulated decreased and the number that was severely degranulated increased. There was no change in mast cell integrity in biopsies from heart and skin, and in peritoneal fluid after 14-day administration of 0.1 mg/kg/day. However, the number of mast cells associated with the small intestine that had undergone degranulation was increased at this dose of malathi...Continue Reading

Citations

Aug 1, 1997·International Journal of Immunopharmacology·K Rodgers, S Xiong
Apr 27, 2001·Toxicology Letters·D E Ray, P G Richards
Mar 13, 2008·Environmental Health Perspectives·Becky J ProskocilAllison D Fryer
Feb 5, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Becky J ProskocilAllison D Fryer
Jan 29, 2016·Journal of Cellular and Molecular Medicine·Peng LiChang-Ping Hu
Feb 22, 2012·Neurotoxicology·Christopher N Banks, Pamela J Lein
Nov 6, 2001·Immunopharmacology and Immunotoxicology·U Undeğer, N Başaran
Jul 11, 2008·Environmental Toxicology and Chemistry·Sarah A BudischakWilliam A Hopkins
Jun 29, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Frances C ShaffoPamela J Lein
May 13, 1999·Journal of Toxicology and Environmental Health. Part a·J R BeamanJ T Zelikoff
Jul 7, 2000·Clinical and Diagnostic Laboratory Immunology·K RodgersG S diZerega
Apr 25, 2007·International Journal of Toxicology·Zayil SalazarHumberto González-Márquez
Jan 26, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Prem RajakSumedha Roy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.