PMID: 6048785Aug 1, 1967Paper

Effect of administration of the carcinogen dimethylnitrosamine on urinary 7-methylguanine

The Biochemical Journal
V M CRADDOCK, P N Magee

Abstract

1. Evidence is presented for the excretion of 7-methylguanine in normal rat urine at a rate of approx. 65mug./day. Experiments with animals in which the nucleic acids had been prelabelled by treatment of the neonatal rats with [(14)C]-formate gave evidence that the methylated base originated in the nucleic acids of the rat. 2. Injection of [(14)C]dimethylnitrosamine leads to an increased excretion of 7-methylguanine, and the base becomes labelled in the methyl group. The disappearance of labelled 7-methylguanine formed in nucleic acids of rats treated with the carcinogen therefore does not take place by an N-demethylation reaction, but by liberation of the intact methylated base.

Citations

Jun 1, 1984·Ecotoxicology and Environmental Safety·S M ZayedB Hegazi
May 1, 1974·Chemico-biological Interactions·R Wennerberg, G Löforth
Nov 1, 1974·Archives of Environmental Health·H Low
Apr 23, 1979·Archives of Toxicology·A S WrightM F Wooder
Jan 1, 1982·Teratogenesis, Carcinogenesis, and Mutagenesis·M SorsaH Vainio
Oct 1, 1993·Environmental Health Perspectives·D E ShukerH Bartsch
Mar 1, 1993·Environmental Health Perspectives·J S WishnokC D Leaf
Mar 1, 1993·Environmental Health Perspectives·D E ShukerH Bartsch
Jan 1, 1972·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·P WeylandH Dannenberg
Apr 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D G Lindsay
Mar 15, 1982·Chemico-biological Interactions·K Hemminki

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