Effect of adrenalectomy and corticosterone replacement on epididymal carbohydrate metabolism--studies on mature male rats

Andrologia
K BalasubramanianP Govindarajulu

Abstract

The effect of adrenalectomy and corticosterone replacement on epididymal enzymes involved in obligatory steps of glycolysis and pentose phosphate pathway were studied along with serum hormonal profiles. Adrenalectomy was found to elevate serum prolactin while the gonadotropins and testosterone were unaltered. In caput epididymal tissue enzymes of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities were increased after adrenalectomy. However, in corpus epididymal tissue the key enzymes viz. hexokinase, 6-phosphofructokinase and pyruvatekinase of the glycolytic pathway were elevated leaving the pentose phosphate pathway unaffected. Adrenalectomy was also found to favour glycolysis of the epididymal spermatozoa. The possible direct effect of prolactin is discussed to explain the enzymatic changes in epididymis. Corticosterone replacement was found to maintain the enzyme activities along with serum prolactin and corticosterone at control levels. In conclusion, it is suggested that the adrenalectomy induced changes in enzyme activities could be due to the direct effect of prolactin.

References

Sep 1, 1975·Endocrinology·C Aragona, H G Friesen
Nov 1, 1977·Biology of Reproduction·M W Hostetter, B E Piacsek
Aug 1, 1965·Endocrinology·H D Purves, N E Sirett
Feb 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·S A Sholl, J H Leathem
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Jul 1, 1981·Acta paediatrica Scandinavica·R MarilusZ Laron

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Citations

Mar 1, 1987·Journal of Andrology·K BalasubramanianP Govindarajulu

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