PMID: 9179570May 1, 1997Paper

Effect of adrenaline and alpha-agonists on net rate of liquid absorption from the pleural space of rabbits

Experimental Physiology
L ZocchiE Agostoni

Abstract

Indirect evidence supporting a solute-coupled liquid absorption from the pleural space of rabbits has recently been provided; moreover, the beta 2-adrenoceptor agonist terbutaline has been found to increase this absorption. In this study the effect of adrenaline and alpha-adrenoceptor agonists on net rate of liquid absorption (Jnet) from albumin Ringer hydrothoraces of various sizes has been determined in anaesthetized rabbits. In hydrothoraces with adrenaline (5 x 10(-6) M) the relationship between Jnet and volume of liquid injected was displaced upwards by 0.09 ml h-1 relative to that in control hydrothoraces (P < 0.01). This displacement did not occur with lower adrenaline concentrations or after pretreatment with the beta-blocker propranolol. Hence, this increase in Jnet is mediated by stimulation of beta-receptors. It seems to be caused by an increase in solute-coupled liquid absorption, since beta-agonists inhibit lymphatic activity while, at relatively high concentrations, they may increase active transport. Conversely, the strong stimulation of lymphatic alpha-receptors that should occur with adrenaline after beta-blockade may fail to increase lymphatic drainage, because it has been shown that the increase in contractio...Continue Reading

Citations

Mar 2, 2016·Biotechnology Progress·Ying Lei, Zannatul Ferdous
Jan 13, 2006·European Journal of Pharmacology·Konstantinos VogiatzidisPaschalis-Adam Molyvdas
Mar 27, 2004·Physiological Reviews·Stephen J Lai-Fook
May 29, 2015·Current Opinion in Pulmonary Medicine·Sotirios G Zarogiannis, Ioannis Kalomenidis

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