PMID: 6103854May 1, 1980Paper

Effect of adrenergic agents on the secretion of gastrointestinal immunoreactive glucagon in depancreatized dogs

Diabetes
T Yoshida, M Kondo

Abstract

To elucidate the mode of action of adrenergic agents on gastric A cells, the effects of infusion of adrenergic agonists and antagonists on the secretion of gastrointestinal immunoreactive glucagon (gastrointestinal IRG) from gastric A cells were investigated in 45 conscious, depancreatized dogs untreated with insulin. Large amounts (0.6 micrograms/kg/min) of epinephrine, norepinephrine, and isoproterenol stimulated the release of gastrointestinal IRG, and catecholamine-induced gastrointestinal IRG release was completely abolished by simultaneous infusion of the specific beta receptor-blocking compound, propranolol, but not by alpha receptor blockade with phentolamine. These findings suggest that, when adrenergic agonists are infused in large amounts, they may act through a beta receptor to increase the release of gastrointestinal IRG.

Citations

Nov 14, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Henry C LinJin Hai Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.