PMID: 6990782May 1, 1980Paper

Effect of adrenergic agonists on big and small renin

The American Journal of Physiology
H IwaoA M Michelakis

Abstract

The effect of alpha- and beta-adrenergic agonists on renal and submaxillary renin of different molecular weights was studied using male albino mice as experimental animals. Phenylephrine or isoproterenol was administered intravenously after removal of the submaxillary glands and/or kidneys. Renin was isolated from plasma by column chromatography and then measured by a direct radioimmunoassay. Phenylephrine increased both 68,500-dalton renin (big renin) and 38,000-dalton renin (small renin) in the plasma of nephrectomized mice. Isoproterenol increased big and small renin in the plasma of mice whose submaxillary glands were removed. In both cases, the increase of small renin was significantly greater than that of big renin. The results suggest that the alpha-adrenergic agonist phenylephrine affects the submaxillary gland, leading to the increase of both big and small plasma renin. In contrast, the beta-adrenergic agonist isoproterenol affects the kidney, leading to the increase of both big and small plasma renin.

References

Sep 4, 1976·Lancet·F H DerkxM A Schalekamp
Jun 1, 1975·The Journal of Clinical Endocrinology and Metabolism·R P DayC M Gonzales
Feb 26, 1979·Biochimica Et Biophysica Acta·A H NielsenK Poulsen
Dec 15, 1978·The Biochemical Journal·S FunakawaK Yamamoto
Jan 1, 1979·Circulation Research·M D BailieM A Schalekamp
Mar 1, 1977·Kidney International·C F de SenarclensM B Vallotton
Nov 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·H YoshidaA M Michelakis
Dec 1, 1974·The American Journal of Physiology·J W MenzieH Yoshida
May 1, 1969·The American Journal of Physiology·T TakedaA Grollman

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