PMID: 2879022Nov 1, 1986

Effect of adrenergic drugs on the isolated colon of Rhesus cynomolgus

The Journal of Pharmacy and Pharmacology
A Grivegnee, J Fontaine

Abstract

The effects of adrenaline, noradrenaline, isoprenaline and dopamine were studied on the longitudinal muscle of the ascending and descending colon of the rhesus monkey. All these drugs induced a relaxation of the preparation, dopamine being the less active agonist. The responses seem to be the result of beta 2-adrenoceptor stimulation since their inhibition by practolol (beta 1) is weaker than their inhibition by propranolol (beta 1 and beta 2 dopaminergic). There is no evidence for the presence of dopaminergic receptors in this preparation.

References

Feb 1, 1970·British Journal of Pharmacology·W C Bowman, M T Hall
Jan 8, 1982·European Journal of Pharmacology·B Ek, B Lundgren
Jul 1, 1984·The Journal of Pharmacy and Pharmacology·A GrivegneeJ Reuse
Feb 1, 1984·British Journal of Pharmacology·J FontaineJ Reuse

Citations

Dec 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·P BrikasJ Fioramonti

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