Effect of Aerobic Exercise Training and Essential Amino Acid Supplementation for 24 Weeks on Physical Function, Body Composition, and Muscle Metabolism in Healthy, Independent Older Adults: A Randomized Clinical Trial.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Melissa M MarkofskiElena Volpi

Abstract

Essential amino acids (EAA) and aerobic exercise (AE) acutely and independently stimulate skeletal muscle protein anabolism in older adults. In this Phase 1, double-blind, placebo-controlled, randomized clinical trial, we determined if chronic EAA supplementation, AE training, or a combination of the two interventions could improve muscle mass and function by stimulating muscle protein synthesis. We phone-screened 971, enrolled 109, and randomized 50 independent, low-active, nonfrail, and nondiabetic older adults (age 72 ± 1 years). We used a 2 × 2 factorial design. The interventions were: daily nutritional supplementation (15 g EAA or placebo) and physical activity (supervised AE training 3 days/week or monitored habitual activity) for 24 weeks. Muscle strength, physical function, body composition, and muscle protein synthesis were measured before and after the 24-week intervention. Forty-five subjects completed the 24-week intervention. VO2peak and walking speed increased (p < .05) in both AE groups, irrespective of supplementation type, but muscle strength increased only in the EAA + AE group (p < .05). EAA supplementation acutely increased (p < .05) muscle protein synthesis from basal both before and after the intervention,...Continue Reading

Associated Clinical Trials

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Citations

Mar 25, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rachel R DeerElena Volpi
Nov 16, 2019·Nature Reviews. Endocrinology·Bettina MittendorferLuigi Fontana
Sep 19, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Roger A Fielding
Jun 20, 2020·Annual Review of Nutrition·Emily W FlanaganLeanne M Redman
Jul 1, 2020·Journal of Aging and Physical Activity·Ashley A HerdaJoel T Cramer
May 28, 2019·Translational Sports Medicine·Camille R BrightwellBlake B Rasmussen
Dec 29, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yen-Nung LinChih-Yang Hsu
Feb 4, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Junjie WangGuohao Wu

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