Effect of Aerosol Devices and Administration Techniques on Drug Delivery in a Simulated Spontaneously Breathing Pediatric Tracheostomy Model

Respiratory Care
Bshayer AlHamadArzu Ari

Abstract

This study was conducted to compare the efficiency of jet nebulizers, vibrating mesh nebulizers, and pressurized metered-dose inhalers (pMDI) during assisted and unassisted administration techniques using a simulated spontaneously breathing pediatric model with a tracheostomy tube (TT). An in vitro breathing model consisting of an uncuffed TT (4.5-mm inner diameter) was attached to a collecting filter (Respirgard) connected to a dual-chamber test lung and a ventilator (Hamilton Medical) to simulate breathing parameters of a 2-y-old child (breathing frequency, 25 breaths/min; tidal volume, 150 mL; inspiratory time, 0.8 s; peak inspiratory flow, 20 L/min). Albuterol sulfate was administered using a jet nebulizer (MicroMist, 2.5 mg/3 mL), vibrating mesh nebulizer (Aeroneb Solo, 2.5 mg/3 mL), and pMDI (ProAir HFA, 432 μg). Each device was tested 5 times with an unassisted technique (direct administration of aerosols with simulated spontaneous breathing) and with an assisted technique (using a manual resuscitation bag in conjunction with an aerosol device and synchronized with inspiration). Drug collected on the filter was analyzed by spectrophotometry. With the unassisted technique, the pMDI had the highest inhaled mass percent (IM...Continue Reading

Citations

Oct 8, 2016·Critical Care : the Official Journal of the Critical Care Forum·Jayesh DhananiJason A Roberts
Jan 12, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Ariel BerlinskiIsrael Amirav
Feb 24, 2017·Expert Review of Respiratory Medicine·Arzu Ari, James B Fink
Jan 22, 2020·Expert Opinion on Drug Delivery·Arzu Ari, James B Fink
Mar 28, 2021·BMJ Open Respiratory Research·Marc Mac Giolla EainRonan MacLoughlin
Jun 12, 2021·Biomedical Engineering Online·Hyun Mok ParkKi Chang Nam
Oct 15, 2021·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Hui-Yun TsengHan-Sun Chiang

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