Effect of aescine on hypoxia-induced activation of human endothelial cells

European Journal of Pharmacology
T ArnouldJ Remacle

Abstract

Phlebotonic drugs are very often old drugs which improve symptoms in chronic venous insufficiency but their precise mechanism remains unclear. One reason for this lack of information is our poor understanding of the aetiology of the varicose vein. One hypothesis which is being more and more substantiated is that the origin of the disease lies in the activation of the endothelium during blood stasis, leading to a cascade of reactions which, in the long term, alter the structure of the vein wall. In this work, we tested aescine (Reparil i.v. form), a phlebotonic drug, in an in vitro model which mimics this situation, i.e. human endothelial cells exposed to hypoxic conditions. Aescine was shown to inhibit 2 important steps of the activation of endothelial cells incubated 120 min under hypoxia the decrease in ATP content, which is the starting point of the activation cascade, and the increase in the activity of phospholipase A2, an enzyme responsible for the release of precursors of inflammatory mediators. Hypoxia-activated endothelial cells also increase their adhesiveness for neutrophils. This process could also be prevented in a dose-dependent manner if endothelial cells were incubated in the presence of aescine. This inhibition...Continue Reading

References

Jun 1, 1976·Scandinavian Journal of Immunology·A Bøyum
Jul 1, 1992·Journal of Cellular Physiology·T ArnouldJ Remacle
Nov 1, 1973·The Journal of Clinical Investigation·E A JaffeR L Nachman
Apr 1, 1993·The American Journal of Physiology·C MichielsJ Remacle

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Citations

May 15, 2002·European Journal of Pharmacology·Najat BouazizCarine Michiels
May 21, 1998·European Journal of Pharmacology·C BougeletC Michiels
Apr 2, 2008·The Journal of General Physiology·Giedrius KanaporisVirginijus Valiunas
Jan 11, 2001·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·D A Redman
Feb 6, 2007·Journal des maladies vasculaires·N Danziger
Nov 3, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Wenyu XinFenghua Fu
May 22, 2007·Vascular Pharmacology·Omar F Carrasco, Horacio Vidrio
Jul 3, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J Glowinski, S Glowinski
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Onur ElmasGurkan Yigitturk
Feb 18, 2018·The Journal of General Physiology·Felix NeumaierToni Schneider
Sep 1, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C R Sirtori
Jun 6, 2000·Biochimica Et Biophysica Acta·C MichielsJ Remacle

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