Oct 1, 1975

Effect of aflatoxin B1 on pyridine nucleotides and NADP linked dehydrogenases

British Journal of Experimental Pathology
N Singh, T A Venkitasubramanian

Abstract

The effect of a single interaperitoneal injection (6 mg/kg body weight) of aflatoxin B1 in propylene glycol on pyridine nucleotides and NDP linked dehydrogenases was studied 24 h after administration of the toxin. The liver showed a decrease in total proteins and pyridine nucleotides though levels of NADP and NADPH remained unchanged. Levels of NAD and NADH were decreased. The activities of hepatic of hwpRIX of hepatic malate dehydrogenase (MDH) and isocitrate dehydrogenase (ICDH) were not altered though ICDH showed an increase when expressed on protein basis. However, there was a significance decrease in the activity of combined HMP dehydrogenases. Adipose tissue showed increased activities of the HMP dehydrogenasess.

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Mentioned in this Paper

Pyridines
Fat Pad
Propylene Glycol
Malate Dehydrogenase
Toxin
Aflatoxins
Weighing Patient
Hepatic
NADH
Pyridine

About this Paper

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