Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR). Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function. Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors. We show that there is no effect of age or refractive error on ipRGC inputs to the human pupil control pathway. The stability of the ipRGC mediated pupil response across the human lifespan provides a functional correlate of their robustness observed during ageing in rodent models.
Apomorphine blocks form-deprivation myopia in chickens by a dopamine D2-receptor mechanism acting in retina or pigmented epithelium
Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN
Effects of age on optical coherence tomography measurements of healthy retinal nerve fiber layer, macula, and optic nerve head
Chromatic pupil responses: preferential activation of the melanopsin-mediated versus outer photoreceptor-mediated pupil light reflex
The influence of intrinsically-photosensitive retinal ganglion cells on the spectral sensitivity and response dynamics of the human pupillary light reflex
Intrinsically photosensitive melanopsin retinal ganglion cell contributions to the pupillary light reflex and circadian rhythm
Dopaminergic agonists that result in ocular growth inhibition also elicit transient increases in choroidal thickness in chicks
Normative data set identifying properties of the macula across age groups: integration of visual function and retinal structure with microperimetry and spectral-domain optical coherence tomography
Test-retest repeatability of the pupil light response to blue and red light stimuli in normal human eyes using a novel pupillometer
Toward a clinical protocol for assessing rod, cone, and melanopsin contributions to the human pupil response
The post-illumination pupil response of melanopsin-expressing intrinsically photosensitive retinal ganglion cells in diabetes
Neuron numbers in the hypothalamus of the normal aging rhesus monkey: stability across the adult lifespan and between the sexes
Protective effects of high ambient lighting on the development of form-deprivation myopia in rhesus monkeys
The improving outcomes in intermittent exotropia study: outcomes at 2 years after diagnosis in an observational cohort
Intrinsically photosensitive retinal ganglion cell function in relation to age: a pupillometric study in humans with special reference to the age-related optic properties of the lens
Circadian and wake-dependent effects on the pupil light reflex in response to narrow-bandwidth light pulses
Monochromatic Pupillometry in Unilateral Glaucoma Discloses no Adaptive Changes Subserved by the ipRGCs
Inherited Photoreceptor Degeneration Causes the Death of Melanopsin-Positive Retinal Ganglion Cells and Increases Their Coexpression of Brn3a
Rhodopsin and Melanopsin Contributions to the Early Redilation Phase of the Post-Illumination Pupil Response (PIPR)
Loss of Melanopsin-Expressing Ganglion Cell Subtypes and Dendritic Degeneration in the Aging Human Retina
Chromatic Pupillometry Methods for Assessing Photoreceptor Health in Retinal and Optic Nerve Diseases
Myopia, or near-sightedness, is associated with delayed melatonin circadian timing and lower melatonin output in young adult humans.
Ocular Health of Octodon degus as a Clinical Marker for Age-Related and Age-Independent Neurodegeneration.
Intrinsically photosensitive retinal ganglion cell-driven pupil responses in patients with traumatic brain injury.
Ambient-task combined lighting to regulate autonomic and psychomotor arousal levels without compromising subjective comfort to lighting.
Aging Genetics (Keystone)
This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.