Abstract
Avibactam is a novel non-β-lactam β-lactamase inhibitor currently being assessed in combination with ceftazidime, ceftaroline fosamil, and aztreonam. The objectives of this study were to investigate the pharmacokinetics, safety, and tolerability of avibactam in healthy young (aged 18-45 years) and elderly (aged ≥65 years) volunteers of both sexes. This was a Phase I, open-label study in which healthy volunteers aged ≥18 years were enrolled into 4 cohorts: young male, young female, elderly male, and elderly female (n = 8 in each group). Subjects were excluded if they had any condition requiring regular medication or any other relevant conditions. All subjects received a single dose of avibactam 500 mg/100 mL given intravenously over 30 minutes. Pharmacokinetic measurements included Cmax, Tmax, AUC0-∞, plasma clearance, and t½. Within the two age categories the mean age across male and female subjects was well matched. The majority of subjects in the young cohort were black (≥62.5%), whilst the majority of those in the elderly cohorts were white (≥75%). Mean avibactam plasma clearance was similar between the young male, young female, and elderly male cohorts (10.16, 10.34, and 9.82 L/h, respectively), and slightly lower in elderl...Continue Reading
References
Jun 17, 2009·Antimicrobial Agents and Chemotherapy·Andrea EndimianiRobert A Bonomo
May 14, 2010·The New England Journal of Medicine·Anton Y Peleg, David C Hooper
Oct 6, 2010·Antimicrobial Agents and Chemotherapy·Thérèse StachyraMichael T Black
Nov 3, 2010·Antimicrobial Agents and Chemotherapy·David M LivermoreNeil Woodford
Nov 3, 2010·Antimicrobial Agents and Chemotherapy·Andrea EndimianiRobert A Bonomo
Mar 3, 2011·Mayo Clinic Proceedings·Souha S Kanj, Zeina A Kanafani
Oct 18, 2011·Emerging Infectious Diseases·Patrice NordmannLaurent Poirel
Jun 27, 2012·Antimicrobial Agents and Chemotherapy·Mariana CastanheiraRonald N Jones
Nov 14, 2012·Current Medical Research and Opinion·José A VazquezCarole Sable
Feb 9, 2013·The Journal of Antimicrobial Chemotherapy·Christopher LucastiCarole Sable
Mar 13, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Karthick VishwanathanShampa Das
Citations
Oct 1, 2015·Expert Review of Clinical Pharmacology·Yogesh MawalAngela K Talley
Nov 28, 2015·Drugs·Young R LeeGregory K Perry
Oct 27, 2015·International Journal of Antimicrobial Agents·Karen Bush
Oct 31, 2015·Pharmacology Research & Perspectives·Shampa DasTimi Edeki
Jul 3, 2015·The Journal of Antimicrobial Chemotherapy·David P NicolauShampa Das
Jun 17, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Nobumitsu TominagaShampa Das
Mar 31, 2015·Clinical Drug Investigation·Henri MerdjanAntoine Tarral
Apr 22, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David van Duin, Robert A Bonomo
Oct 7, 2016·Acta Pharmaceutica Sinica. B·Wenli LiuMingshi Yang
Nov 1, 2016·Expert Opinion on Pharmacotherapy·Sara A BuckmanJohn E Mazuski
Jul 25, 2017·Clinical Pharmacology and Therapeutics·C-H HsuehS-M Huang
Nov 8, 2017·Infection·Felipe Francisco TuonMarcelo R Formigoni-Pinto
Sep 30, 2017·The Journal of Antimicrobial Chemotherapy·David M LivermoreNeil Woodford
Jul 1, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Karen ChengAngela Wardman
Dec 10, 2015·Clinical Drug Investigation·Jianguo LiTimi Edeki
Aug 12, 2018·Clinical Pharmacokinetics·Sherwin K B SyHartmut Derendorf
Apr 20, 2018·Drugs·Matt Shirley
Apr 4, 2021·International Journal of Molecular Sciences·Silvia López-ArgüelloBartolome Moya