Aug 30, 2014

Effect of age, gender and mannose-binding lectin (MBL) status on the inflammatory profile in peripheral blood plasma of Australian blood donors

Human Immunology
Katrina KildeyM M Dean

Abstract

Transfusion of blood components has been associated with poor patient outcomes and, an overall increase in morbidity and mortality. Differences in the blood components arising from donor health, age and immune status may impact on outcomes of transfusion and transfusion-related immune modulation in recipients. The aim of this study was to investigate differences in inflammatory profile in donors and association with parameters including age, gender and deficiency status of pattern recognition molecule mannose-binding lectin (MBL). MBL level was determined by ELISA. Serum levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, IL-12, tumour necrosis factor (TNF)-α, macrophage inflammatory protein (MIP)-1α, monocyte chemoattractant protein (MCP)-1, interferon (IFN)-α, and IFN-γ were examined by cytometric bead array (CBA). C-reactive protein (CRP) and rheumatoid factor (RF) were examined by immunoturbidimetry. This study demonstrated age was a parameter associated with the immune profile of blood donors, with significant increases in MCP-1 (p<0.05) and RF (p<0.05) and decreases in IL-1α evident in the older donors (61-76years). Significant gender-associated differences in MCP-1, IL-12 and CRP plasma levels in the blood donor coh...Continue Reading

  • References42
  • Citations3

References

Mentioned in this Paper

Respiratory Syncytial Virus Infections
Immune Response
Flow Cytometry
Immune System
Autoantibodies
Macrophage Inflammatory Proteins
Morbidity Aspects
Tumor Necrosis Factor-alpha
C-reactive Protein Measurement
Systemic Inflammatory Response Syndrome

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