PMID: 6397024Oct 1, 1984Paper

Effect of age on Agaricus bisporus PHA-B stimulated insulin release and 45Ca2+ uptake in vitro by islets of Langerhans

Acta diabetologica latina
N AhmadJ R Kidwai

Abstract

The in vitro basal insulin release and 45Ca2+ uptake by rat islets of Langerhans remain unaffected by the animal's age. However, when Agaricus bisporus lectin PHA-B is added to the medium, there is a significant stimulation of basal insulin secretion and 45Ca2+ uptake. The islets isolated from younger rats are more sensitive to A. bisporus PHA-B stimulation and register 1.5-fold and 3-fold more increases of insulin release and 45Ca2+ uptake respectively as compared to islets isolated from 12-month-old rats. Age-related conformational changes in the B-cell membrane are suggested as a possible explanation for the above observation.

References

Aug 1, 1979·The Journal of Clinical Investigation·E P ReavenG M Reaven
Apr 27, 1979·Biochemical and Biophysical Research Communications·A Kitahara, R C Adelman
Jan 1, 1976·The Journal of Physiology·B HellmanI B Täljedal
Sep 1, 1968·Endocrinology·D L CurryG M Grodsky
Nov 1, 1968·British Journal of Pharmacology·W W Douglas
Oct 1, 1971·The Journal of Clinical Endocrinology and Metabolism·J B O'SullivanR F Williams
Feb 1, 1982·Acta Physiologica Scandinavica·T AnderssonB Hellman
Jan 1, 1980·Diabetologia·G M Reaven, P D Reaven
Dec 20, 1976·Biochemical and Biophysical Research Communications·G GoldR C Adelman

❮ Previous
Next ❯

Citations

Mar 1, 1997·The Proceedings of the Nutrition Society·A M Gray, P R Flatt
May 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wangsa Tirta IsmayaHeni Rachmawati

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
J BuceriusH-J Biersack
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
H Sasamoto
British Medical Journal
© 2021 Meta ULC. All rights reserved