Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline

The American Journal of Physiology
L A FrassettoA Sebastian

Abstract

In 64 apparently healthy adult humans (ages 17-74 yr) ingesting controlled diets, we investigated the separate and combined effects of age, glomerular filtration rate (GFR, index of age-related renal functional decline), renal net acid excretion [NAE, index of endogenous acid production (EAP)], and blood PCO2 (PbCO2, index of respiratory set point) on steady-state blood hydrogen ion ([H+]b) and plasma bicarbonate concentration ([HCO3-]p). Independent predictors of [H+]b and [HCO3-]p were PbCO2, NAE, and either age or GFR, but not both, because the two were highly correlated (inversely). [H+]b increased with increasing PbCO2, NAE, and age and with decreasing GFR. [HCO3-]p decreased with increasing NAE and age but increased with increasing PbCO2 and GFR. Age (or GFR) at constant NAE had greater effect on both [H+]b and [HCO3-]p than did NAE at constant age (or GFR). Neither PbCO2 nor NAE correlated with age or GFR. Thus two metabolic factors, diet-dependent EAP and age (or GFR), operate independently to determine blood acid-base composition in adult humans. Otherwise healthy adults manifest a low-grade diet-dependent metabolic acidosis, the severity of which increases with age at constant EAP, apparently due in part to the normal...Continue Reading

Citations

Jun 28, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Julia J SciallaCheryl A M Anderson
Aug 26, 2015·Seminars in Dialysis·Arnold J FelsenfeldMariano Rodriguez
Aug 29, 2019·American Journal of Physiology. Renal Physiology·Emily E SchmittDanielle R Bruns
Dec 22, 2017·Critical Reviews in Food Science and Nutrition·Behnaz Abiri, Mohammadreza Vafa
Apr 25, 2018·Nutrients·Lynda FrassettoAnthony Sebastian
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M Mac LaughlinC Amorena
Dec 1, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Roberto Mioni, Giuseppe Mioni
Jun 22, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Daniela FlückCarsten Lundby
Jan 13, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H LambertS Lanham-New
Oct 20, 2017·Nephron·Negiin PourafsharManoocher Soleimani
Jan 2, 2019·International Journal of Molecular Sciences·Nicola Baldini, Sofia Avnet

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