PMID: 2491757Jan 1, 1989Paper

Effect of age on brain cortical protein kinase C and its mediation of 5-hydroxytryptamine release

Journal of Neurochemistry
E Friedman, H Y Wang

Abstract

The effects of age on the activity and translocation of protein kinase C (PKC) and on the facilitation of 5-hydroxytryptamine (5-HT, serotonin) release induced by PKC activation with the phorbol ester phorbol 12-myristate 13-acetate were investigated. The activities of cortical PKC and its translocation in response to K+ depolarization and phorbol ester stimulation were reduced during aging in Fischer-344 rats. Parietal cortical brain slices from 6-, 12-, and 24-month-old animals were preloaded with [3H]5-HT and release was evoked by 65 mM K+ or the calcium ionophore A23187. 5-HT release induced by either K+ or A23187 was found to be reduced in 12- and 24-month-old as compared to 6-month-old animals. This decrease was not reversed by high extracellular Ca2+. Activation of PKC resulted in a facilitated transmitter release in tissue from 6- and 12-month-old animals but reduced [3H]5-HT release in slices from 24-month-old animals. These responses were prevented by the putative PKC inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), but not by increasing extracellular or intracellular Ca2+. The results demonstrate an age-related change (1) in brain PKC activity and translocation and (2) in a physiological response to PKC...Continue Reading

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Citations

Jan 1, 1994·Journal of Neural Transmission. General Section·T ArakiK Kogure
Dec 1, 1995·Molecular and Chemical Neuropathology·R E Cashman, P Grammas
Dec 1, 1995·Molecular and Chemical Neuropathology·P MooreP Grammas
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Sep 6, 2002·Experimental Gerontology·Hyon Jeen KimHae Young Chung

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