Jul 1, 1977

Effect of age on human adipose tissue metabolism and hormonal responsiveness

Acta paediatrica Scandinavica
G NybergU Smith


The effects of age and fat cell size on the metabolism of white human adipose tissue were analysed independently. Abdominal subcutaneous adipose tissue specimens were obtained from children varying in age from 0-15 years and from adults (mean age +/- S.D.; 38.2 +/- 14.1 years). The basal rates of lipolysis and glucose incorporation into lipids were considerably higher in children than in adults even when differences in fat cell size had been taken into account. Lipolysis in response to a maximal concentration of noradrenalin was higher in fat cells from children. However, on a percentage basis the responsiveness to this agent was similar in children and adults. Irrespective of age, glucagon did not elicit a lipolytic response. Thus, it does not seem that the increased lipolysis known to occur in vivo in the neonatal period is due to a direct effect of glucagon on white adipose tissue. However, the overall lipolytic capacity is increased in fat cells from children.

Mentioned in this Paper

Fat Pad
Glucose, (beta-D)-Isomer
Norepinephrine, (+, -)-Isomer
Lipid Metabolism

About this Paper

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.