Effect of age on long-term facilitation and chemosensitivity during NREM sleep

Journal of Applied Physiology
Susmita ChowdhuriM S Badr

Abstract

The reason for increased sleep-disordered breathing with a predominance of central apneas in the elderly is unknown. We speculate that ventilatory control instability may provide a link between aging and the onset of unstable breathing during sleep. We sought to investigate potential underlying mechanisms in healthy, elderly adults during sleep. We hypothesized that there is 1) a decline in respiratory plasticity or long-term facilitation (LTF) of ventilation and/or 2) increased ventilatory chemosensitivity in older adults during non-, this should be hyphenated, non-rapid rapid eye movement (NREM) sleep. Fourteen elderly adults underwent 15, 1-min episodes of isocapnic hypoxia (EH), nadir O2 saturation: 87.0 ± 0.8%. Measurements were obtained during control, hypoxia, and up to 20 min of recovery following the EH protocol, respectively, for minute ventilation (VI), timing, and inspiratory upper-airway resistances (RUA). The results showed the following. 1) Compared with baseline, there was a significant increase in VI (158 ± 11%, P < 0.05) during EH, but this was not accompanied by augmentation of VI during the successive hypoxia trials nor in VI during the recovery period (94.4 ± 3.5%, P = not significant), indicating an absenc...Continue Reading

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Citations

May 24, 2016·High Altitude Medicine & Biology·Valerii B ShatyloOleg V Korkushko
Dec 23, 2016·Chest·Susmita Chowdhuri, M Safwan Badr
Oct 14, 2017·Journal of Applied Physiology·Susmita ChowdhuriM Safwan Badr
Sep 25, 2020·Journal of Applied Physiology·Ruchi RastogiS Chowdhuri

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