Effect of age on survival and causes of death after primary prevention implantable cardioverter-defibrillator implantation

The American Journal of Cardiology
Laurent FauchierDAI-PP Investigators

Abstract

The benefit of implantable cardioverter-defibrillators (ICDs) remains controversial in elderly patients and may be attenuated by a greater risk of nonarrhythmic death. We examined the effect of age on outcomes after prophylactic ICD implantation. All patients with coronary artery disease or dilated cardiomyopathy implanted with an ICD for primary prevention of sudden cardiac death in 12 French medical centers were included in a retrospective observational study. The 5,534 ICD recipients were divided according to age: 18 to 59 years (n = 2,139), 60 to 74 years (n = 2,693), and ≥75 years (n = 702). Greater prevalences of coronary artery disease and atrial fibrillation at the time of implant were observed with increasing age (both p <0.0001). During a mean follow-up of 3.1 ± 2.0 years, the annual mortality rate increased with age: 3.1% per year for age 18 to 59 years, 5.7% per year for age 60 to 74 years, and 7.5% per year for age ≥75 years (p <0.001). Older age was independently associated with a greater risk of death (adjusted odds ratio 1.43, 95% confidence interval 1.14 to 1.80 for age 60 to 74 years; and adjusted odds ratio 1.65, 95% confidence interval 1.22 to 2.22 for age >75 years). Proportions of cardiac deaths (55.2%, 57...Continue Reading

References

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Citations

Jul 22, 2016·International Journal of Cardiology·Tilman PerrinUNKNOWN DAI-PP Investigators
Sep 14, 2016·Journal of Electrocardiology·Joachim SeegersMarkus Zabel
Jan 14, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Nelly AmaraUNKNOWN DAI-PP Investigators
Apr 1, 2020·European Journal of Heart Failure·Nathaniel M HawkinsMark C Petrie
Nov 17, 2020·Frontiers in Cardiovascular Medicine·Nathan EngstromHayley L Letson
Jul 26, 2018·The Medical Journal of Australia·Bianca BlanchJodie Ingles

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