Abstract
The benefit of implantable cardioverter-defibrillators (ICDs) remains controversial in elderly patients and may be attenuated by a greater risk of nonarrhythmic death. We examined the effect of age on outcomes after prophylactic ICD implantation. All patients with coronary artery disease or dilated cardiomyopathy implanted with an ICD for primary prevention of sudden cardiac death in 12 French medical centers were included in a retrospective observational study. The 5,534 ICD recipients were divided according to age: 18 to 59 years (n = 2,139), 60 to 74 years (n = 2,693), and ≥75 years (n = 702). Greater prevalences of coronary artery disease and atrial fibrillation at the time of implant were observed with increasing age (both p <0.0001). During a mean follow-up of 3.1 ± 2.0 years, the annual mortality rate increased with age: 3.1% per year for age 18 to 59 years, 5.7% per year for age 60 to 74 years, and 7.5% per year for age ≥75 years (p <0.001). Older age was independently associated with a greater risk of death (adjusted odds ratio 1.43, 95% confidence interval 1.14 to 1.80 for age 60 to 74 years; and adjusted odds ratio 1.65, 95% confidence interval 1.22 to 2.22 for age >75 years). Proportions of cardiac deaths (55.2%, 57...Continue Reading
References
Feb 15, 2002·Journal of Cardiovascular Electrophysiology·Jeremy N RuskinMary E McGrory-Usset
Mar 22, 2002·The New England Journal of Medicine·Arthur J MossUNKNOWN Multicenter Automatic Defibrillator Implantation Trial II Investigators
May 8, 2004·American Heart Journal·Andrew D KrahnUNKNOWN ATMA Investigators
May 21, 2004·The New England Journal of Medicine·Michael R BristowUNKNOWN Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators
May 21, 2004·The New England Journal of Medicine·Alan KadishUNKNOWN Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) Investigators
Apr 18, 2006·The American Journal of Cardiology·Joseph J GermanoMark E Josephson
Feb 17, 2007·Pacing and Clinical Electrophysiology : PACE·Wolfram GrimmBernhard Maisch
Mar 21, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Cengiz ErmisDavid G Benditt
Jun 1, 2007·Journal of Cardiovascular Electrophysiology·David T HuangUNKNOWN MADIT-II Research Group
Jun 30, 2007·Journal of the American College of Cardiology·Douglas S LeeAndreas Laupacis
Jan 22, 2008·Journal of the American College of Cardiology·Ilan GoldenbergUNKNOWN MADIT-II Investigators
May 17, 2008·Circulation·Andrew E EpsteinUNKNOWN Society of Thoracic Surgeons
Mar 28, 2009·Circulation·Sharon Ann HuntClyde W Yancy
Nov 3, 2010·Annals of Internal Medicine·Pasquale SantangeliAndrea Natale
Jun 7, 2011·The American Journal of Cardiology·Ure MezuSamir Saba
Mar 6, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Nicolas ClementyDominique Babuty
Oct 2, 2012·Journal of the American College of Cardiology·Kenneth C BilchickAlan Cheng
Nov 8, 2012·The New England Journal of Medicine·Arthur J MossUNKNOWN MADIT-RIT Trial Investigators
Jun 19, 2013·Circulation·Derek YungDouglas S Lee
Dec 10, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mahmoud SuleimanUNKNOWN Israeli Working Group on Pacing and Electrophysiology
Citations
Jul 22, 2016·International Journal of Cardiology·Tilman PerrinUNKNOWN DAI-PP Investigators
Sep 7, 2016·Archives of Cardiovascular Diseases·Laurent FauchierOlivier Hanon
Sep 14, 2016·Journal of Electrocardiology·Joachim SeegersMarkus Zabel
Nov 29, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Lucas V BoersmaUNKNOWN EFFORTLESS and IDE Study Investigators
Jan 14, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Nelly AmaraUNKNOWN DAI-PP Investigators
Jul 28, 2017·Heart·Nathaniel Mark HawkinsJamil Bashir
Jun 25, 2018·ESC Heart Failure·Marcelino CortésJose-Manuel Rubio
Apr 1, 2020·European Journal of Heart Failure·Nathaniel M HawkinsMark C Petrie
Oct 19, 2017·PloS One·Leonard BergauMarkus Zabel
Dec 7, 2016·Journal of Arrhythmia·Daisuke IshigakiIsao Kubota
Nov 17, 2020·Frontiers in Cardiovascular Medicine·Nathan EngstromHayley L Letson
Jul 26, 2018·The Medical Journal of Australia·Bianca BlanchJodie Ingles