Effect of age on survival of critically ill patients with cancer

Critical Care Medicine
Márcio SoaresNelson Spector

Abstract

To estimate the effects of age on 6-month survival of critically ill patients with cancer. Prospective cohort study analyzed using Cox proportional hazard models. Ten-bed oncologic medical-surgical intensive care unit. Eight hundred sixty-two patients with cancer, excluding bone marrow transplant patients. None. The mean age was 57.8+/-16.2 yrs. The hospital and 6-month mortality rates were 48% and 58%, respectively. Age was independently associated with increased mortality (hazard ratio, 1.015; 95% confidence interval, 1.009-1.021). Martingale residual analysis, however, suggested an inflection point in the effect of age, with an upward trend for patients aged>60 yrs. Therefore, patients were stratified in two groups: young (<or=60 yrs, n=431, 50%) and elderly (>60 yrs, n=431, 50%). In young patients, uncontrolled cancer, mechanical ventilation, and number of organ failures were associated with poor outcome, whereas surgery before intensive care unit admission was protective. The variables associated with increased mortality for elderly patients were performance status 3-4, uncontrolled cancer, number of organ failures, and the presence of a severe comorbidity. In this group, age was associated with a lower survival rate. In g...Continue Reading

References

Jul 1, 1990·Critical Care Medicine·D B Chalfin, G C Carlon
Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Dec 22, 1993·JAMA : the Journal of the American Medical Association·J R Le GallF Saulnier
Sep 1, 1996·Acta Anaesthesiologica Scandinavica·G Melltorp, T Nilstun
Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S GroegerS K Kish
Sep 10, 1998·American Journal of Respiratory and Critical Care Medicine·K J PriceB S Andersson
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·J P KressJ B Hall
Dec 6, 2000·JAMA : the Journal of the American Medical Association·D C AngusUNKNOWN Committee on Manpower for Pulmonary and Critical Care Societies (COMPACCS)
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R YancikB Conley
Mar 29, 2001·Intensive Care Medicine·E AzoulayB Schlemmer
Nov 9, 2001·Critical Care Medicine·E AzoulayUNKNOWN PROTOCETIC Group
Oct 24, 2002·Critical Care Medicine·Paul B MassionEtienne Installé
Nov 26, 2002·Intensive Care Medicine·Michael DarmonBenoît Schlemmer
Mar 27, 2003·Journal of the American Geriatrics Society·Mario BoFabrizio Fabris
Jun 10, 2003·Critical Care Medicine·Lakshmipathi ChelluriMichael R Pinsky
Jul 25, 2003·Intensive Care Medicine·E Wesley Ely
Nov 14, 2003·Intensive Care Medicine·Dominique SommeJean-Yves Fagon
Jan 7, 2004·Critical Care Medicine·Lakshmipathi ChelluriMichael R Pinsky
Feb 27, 2004·Intensive Care Medicine·Ariane BoumendilBertrand Guidet
Jul 24, 2004·American Journal of Respiratory and Critical Care Medicine·Theodore J Iwashyna
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Márcio SoaresJosé R Rocco

❮ Previous
Next ❯

Citations

Sep 22, 2009·Intensive Care Medicine·Sébastien RoquesMuriel Fartoukh
May 19, 2010·Intensive Care Medicine·Dominique M VandijckDominique D Benoit
Jun 10, 2008·Critical Care : the Official Journal of the Critical Care Forum·Tobias M MerzHans U Rothen
Dec 3, 2010·Zeitschrift für Gerontologie und Geriatrie·R D PiersN J Van Den Noortgate
Feb 4, 2014·Critical Care Nursing Clinics of North America·Roberta Kaplow
Mar 16, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M M E M BosE de Jonge
Sep 5, 2012·Medicina clínica·Christelle Ferrà, Josep-Maria Ribera
Mar 16, 2007·Chest·Márcio SoaresElie Azoulay
Feb 1, 2014·Chest·Luciano C P AzevedoUNKNOWN Brazilian Research in Intensive Care Network (BRICNet)
May 23, 2015·Blood Reviews·Elie AzoulayUNKNOWN Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique (Grrr-OH)
Dec 1, 2009·Critical Care Clinics·Dominique D Benoit, Eric A Hoste
Dec 1, 2009·Critical Care Clinics·Márcio SoaresJorge I F Salluh
Mar 13, 2014·Journal of Critical Care·Gulbin AygencelMustafa Benekli
Jun 28, 2016·CA: a Cancer Journal for Clinicians·Alexander Shimabukuro-VornhagenMichael S von Bergwelt-Baildon
Jan 25, 2011·QJM : Monthly Journal of the Association of Physicians·S A Ñamendys-SilvaA Herrera-Gómez
Feb 4, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V C Souza-DantasM Soares
Jun 12, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elie AzoulayVirginie Lemiale
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Márcio SoaresNelson Spector
Mar 1, 2006·Critical Care Medicine·Norman A Desbiens
Apr 10, 2009·The American Journal of Hospice & Palliative Care·Silvio A Namendys-SilvaAngel Herrera-Gómez
Jan 11, 2007·The American Journal of Hospice & Palliative Care·Paul E Marik
May 14, 2009·Current Opinion in Oncology·Michael Darmon, Elie Azoulay
Apr 7, 2007·Current Opinion in Anaesthesiology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.