PMID: 15374325Sep 1, 1993Paper

Effect of age on the activity of ceruloplasmin of human blood

Archives of Gerontology and Geriatrics
I SemseiT Fülöp

Abstract

Aminoxidase activity of ceruloplasmin was measured in the serum of 120 people (between 45 and 102 years of age) using the p-phenylenediamine method. A negative linear age-correlation (-30% for the whole lifespan; P < 0.01) was established in this activity with increasing age, nevertheless the total copper content of blood did not change in the same age-range as measured by an atomic absorption spectrophotometric method. Increasing ionic strength, in vitro, caused an exponential decline in blood ceruloplasmin aminoxidase activity of both middle aged and elderly subjects. The age-dependent decrease in ceruloplasmin activity could have a negative effect on the antioxidant functions of blood, and finally on the aging process itself.

References

Mar 1, 1989·Archives of Gerontology and Geriatrics·T FülöpA Leövey
Oct 31, 1989·Biochemical and Biophysical Research Communications·I SemseiA Richardson
Nov 1, 1967·The American Journal of Physiology·G W Evans, R E Wiederanders
Oct 1, 1970·American Journal of Clinical Pathology·S N Sinha, E R Gabrieli
Dec 1, 1984·Archives of Gerontology and Geriatrics·I Semsei, I Nagy
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D Harman
Jan 1, 1981·The International Journal of Biochemistry·R A Løvstad
Mar 27, 1981·Molecular and Cellular Biochemistry·L V PuchkovaS A Neifakh

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Citations

Sep 1, 1996·Biological Trace Element Research·J KadrabováE Ginter
Jan 23, 2009·Journal of Neurology·Kersi J BharuchaElliott D Ross

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