PMID: 3745812Sep 1, 1986Paper

Effect of age on the circadian pattern of sleep and wakefulness in the mouse

Journal of Gerontology
D K WelshW C Dement

Abstract

In elderly humans, daytime naps are common, nocturnal sleep is poorly consolidated, and the sleep period often begins and ends earlier than in young adults. Because previous work has suggested that rodents may provide a useful animal model for these changes, we conducted a detailed investigation of sleep patterns in 11 young adult and 9 old mice. Mice were surgically implanted for chronic EEG recording, and sleep state was monitored over multiple circadian cycles. During the active phase, old mice spent more time asleep and had shorter wake episodes compared with young mice. During the rest phase, old mice spent more time awake than young mice, and tended to have shorter episodes of sleep. No evidence was found, however, for earlier timing of sleep in older mice. These results suggest that the mouse may provide a suitable animal model for further study of certain age-related changes in temporal distribution of sleep and wakefulness.

Citations

Jul 1, 1989·Electroencephalography and Clinical Neurophysiology·G S RuigtL A Van Wezenbeek
Jan 1, 1988·Physiology & Behavior·S S CampbellJ C Hrubovcak
Mar 1, 1995·Physiology & Behavior·B PossidenteA Pabon
May 1, 1994·Physiology & Behavior·S ShibataS Watanabe
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·B L Myers, P Badia
Jan 1, 1996·Pharmacology & Therapeutics·D Dawson, S M Armstrong
Nov 1, 1990·Neurobiology of Aging·R E MistlbergerM C Moore-Ede
May 26, 2004·Brain, Behavior, and Immunity·Linda A Toth, Larry F Hughes
Jan 20, 2004·Neuroscience Letters·Akira TeraoThomas S Kilduff
Oct 19, 2002·Behavioural Brain Research·Takashi Takeuchi, Etsumori Harada
May 16, 2002·Neurobiology of Aging·J Devin McAuleyKevin C H Pang
Oct 24, 2002·Neurobiology of Aging·Rafael J Salin-PascualPriyattam J Shiromani
Dec 17, 2003·Neurobiology of Aging·Kevin C H PangJ Devin McAuley
Oct 26, 2002·Neuroscience Letters·Akira TeraoThomas S Kilduff
Jun 18, 2002·Ageing Research Reviews·S R Pandi-PerumalD F Swaab
Jan 1, 1996·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·G S Richardson, H V Malin
Dec 21, 2013·PloS One·Mathieu E WimmerTed Abel
Jun 27, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nirinjini NaidooAllan I Pack
Apr 1, 1994·Chronobiology International·W WittingD F Swaab
Jan 1, 1997·Chronobiology International·A R MayedaB Possidente
May 12, 2009·Neuroscience and Biobehavioral Reviews·Florent G RevelJean-Luc Moreau
Jan 1, 1995·Advances in Neuroimmunology·L A Toth
Oct 27, 2004·Journal of Psychiatric Research·Andrea DzajaTarja Porkka-Heiskanen
Apr 1, 1991·Medical Hypotheses·S M Armstrong, J R Redman
Dec 3, 2014·Autonomic Neuroscience : Basic & Clinical·Masayoshi KuwaharaKunio Shiota
Jan 1, 1991·Journal of the American Geriatrics Society·M A Brock
Jul 14, 2010·Neurobiology of Aging·Sibah HasanMehdi Tafti
Apr 23, 2010·Neurobiology of Aging·Daniela LupiRussell G Foster
Apr 22, 2015·PloS One·Gideon GradwohlAriel Tarasiuk
May 2, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria RazzoliAlessandro Bartolomucci
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Clarke G TankersleyRobert Frank
Aug 27, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Wen GuoShalender Bhasin
Jan 22, 1998·The American Journal of Physiology·V S ValentinuzziF W Turek
Aug 9, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Sahar FarajniaStephan Michel

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