PMID: 11320102Apr 26, 2001Paper

Effect of age on the gastrointestinal-associated mucosal immune response of humans

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
A A BeharkaS Nibkin Meydani

Abstract

Age-related changes in gastrointestinal-associated mucosal immune response have not been well studied. Thus, we investigated the effect of age on this response and compared these responses to those of peripheral immune cells. Saliva, blood, and intestinal biopsies were collected from young and old healthy subjects to determine immunoglobulin (Ig) levels and to isolate peripheral blood mononuclear cells, intraepithelial lymphocytes (IELs), and lamina propria lymphocytes (LPLs). Although subject age did not influence the level of total IgA found in saliva, IgA levels in serum increased (p <.05) with age. Older subjects' peripheral blood mononuclear cell proliferation and IL-2 production were significantly lower than those of young subjects. LPLs from older subjects produced significantly less IL-2 in response to all stimuli than did that from the young. IEL's ability to proliferate and produce IL-2 was not affected by subject age. Thus, LPL but not IEL demonstrated an age-related decline in immune function similar to that seen in peripheral lymphocytes.

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Citations

Jan 1, 2004·Veterinary Immunology and Immunopathology·Harm HogenEschMichael Hayek
May 23, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yuan Qiu, Hua Yang
Dec 4, 2003·Biological & Pharmaceutical Bulletin·Alice Lok Sze HoHsiao Chang Chan
Aug 11, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Imroze Khan, N G Prasad
Aug 27, 2005·Nutrition Reviews·Ahou MeydaniSimin Nikbin Meydani
Sep 1, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R Spiller, K Garsed
Jun 23, 2009·Trends in Immunology·Kohtaro Fujihashi, Hiroshi Kiyono
Jul 31, 2007·Archives of Oral Biology·S ChaushuG Bachrach
Nov 27, 2004·Mechanisms of Ageing and Development·Kohtaro Fujihashi, Jerry R McGhee
Mar 10, 2005·Dental Clinics of North America·Rigmor E Persson, G Rutger Persson
Nov 19, 2002·Revista Do Instituto De Medicina Tropical De São Paulo·Rubens Silva NascimentoLuiz Carlos Marques de Oliveira
Sep 3, 2019·AIDS Research and Human Retroviruses·Robert L FurlerDouglas F Nixon
Jul 28, 2004·The American Journal of Clinical Nutrition·Oskar AdolfssonRobert M Russell
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raja FayadLiang Qiao
Apr 17, 2009·Analytical Chemistry·Amy L OuelletteGregory T A Kovacs
Apr 27, 2021·Frontiers in Immunology·Samer R KhanLayal Chaker

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