Effect of age on the hemodynamic and sympathetic responses at the onset of isometric handgrip exercise

Journal of Applied Physiology
Sophie LalandeJ Kevin Shoemaker

Abstract

Cardiac and peripheral vasomotor factors contribute to the rapid pressor response at the onset of isometric handgrip exercise. We tested the hypothesis that age enhances the sympathetic and vasoconstrictor response at the onset of isometric handgrip exercise so that the pressor response is maintained, despite a diminished cardiac function. Twelve young and twelve older (24 ± 3 and 63 ± 8 yr) individuals performed 20-s isometric handgrip exercise at 30, 40, or 50% of maximal voluntary contraction force. Muscle sympathetic nerve activity (MSNA) was measured using microneurography. Mean arterial pressure (MAP) and cardiac output (Q) were assessed continuously by finger plethysmography and total peripheral resistance was calculated. MAP increased with the onset of handgrip; this increase was associated with handgrip intensity and was similar in both groups. Heart rate and Q increased with increasing handgrip intensity in both groups, but increases were greater in young vs. older individuals (age × handgrip intensity interaction, P < 0.05). MSNA burst frequency increased (P < 0.01), while MSNA burst incidence tended to increase (P = 0.06) with increasing handgrip intensity in both groups. The change in MSNA between baseline and hand...Continue Reading

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Citations

Oct 9, 2015·European Journal of Applied Physiology·Sophie LalandeJ Kevin Shoemaker
Sep 22, 2015·Frontiers in Physiology·J Kevin Shoemaker, Ruma Goswami
Dec 3, 2014·Autonomic Neuroscience : Basic & Clinical·J Kevin ShoemakerT Luchyshyn
May 12, 2016·The Journal of Headache and Pain·Oleg V MamontovAlexei A Kamshilin
Jul 6, 2017·Experimental Physiology·Evan L MatthewsMegan M Wenner
Dec 5, 2014·Journal of Human Hypertension·J L GreaneyW B Farquhar
Aug 1, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Catherine F NotariusJohn S Floras
Oct 27, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anthony V IncognitoPhilip J Millar
Sep 24, 2020·Physiological Reports·Joseph C WatsoWilliam B Farquhar
Jan 16, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lauro C ViannaJames P Fisher
Feb 12, 2020·Journal of Human Hypertension·Nicholas CauwenberghsTatiana Kuznetsova
Apr 8, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Evan L MatthewsWilliam B Farquhar
Sep 20, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Simranjit K SidhuMarkus Amann
Sep 16, 2017·Journal of Applied Physiology·Joshua R SmithCarl J Ade
Dec 7, 2016·European Journal of Applied Physiology·Alexander BeaumontJoanna Richards
May 29, 2021·Sports Medicine - Open·Blake G Perry, Samuel J E Lucas

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