Effect of aged garlic extract against methotrexate-induced damage to the small intestine in rats

Phytotherapy Research : PTR
Mehmet YüncüAhmet Celik

Abstract

Methotrexate (MTX) chemotherapy is often accompanied by side effects such as gastrointestinal ulceration and diarrhea. The aim of this study was to examine histologically whether an aged garlic extract (AGE) had a protective effect on the small intestine of rats with MTX-induced damage. Forty male Wistar albino rats were randomized into experimental and control groups and divided into four groups of ten animals. To the first group, MTX was applied as a single dose (20 mg/kg) intraperitoneally. To the second group, in addition to MTX application, AGE (250 mg/kg) was administered orally every day at the same time by intragastric intubation until the rats were killed. To the third group, AGE only was given. The fourth group was the control. All animals were killed 4 days after the intraperitoneal injection of MTX for histopathologic analysis and tissue MDA levels. Before killing, intracardiac blood was obtained from each animal to perform biochemical analysis (plasma lactate level). MTX was found to lead to damage in the jejunal tissues and to increase the MDA and lactate levels in the plasma. Administration of the AGE decreased the severity of jejunal damage, but increased MDA and lactate levels caused by MTX treatment on the oth...Continue Reading

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Citations

Jan 26, 2010·Journal of Pediatric Hematology/oncology·Mesut GaripardicErgül Belge Kurutaş
Oct 1, 2014·Indian Journal of Cancer·M Abouhosseini Tabari, S Ebrahimpour
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Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tanvir Ahmed, Chin-Kun Wang

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