PMID: 9181117Oct 1, 1996Paper

Effect of aging on cortical spreading depression

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
R C GuedesN R Teodósio

Abstract

The effects of aging on spreading depression (SD) were investigated in the Mongolian gerbil (G; age range 1.5 to 58 months; N = 35) and in albino rat (R; 2.5 to 24 months; N = 100). Two strains of rats were studied: Wistar (W; N = 35) and Sprague-Dawley (SDAW; N = 65). SDAW rats were divided into two groups: one group was fed a commercial lab chow diet (CD) containing 22% protein (N = 47), and the other was fed a 22% casein diet (CAS; N = 18). SD was elicited on the frontal cortical surface by 1-min application of 2% KCl and its appearance was recorded (ECoG and DC potential) at two points in the parieto-occipital area of the same hemisphere. SD propagation velocity was measured on the basis of the time spent for an SD "wave" to cross the distance between the two recording points. Within the age range studied, older animals displayed significantly lower SD velocities than the younger ones, independent of the species, strain or diet (velocity ranges, in mm/min: G, 2.22-5.99; W, 2.47-4.12; SDAW-CD, 2.32-4.42 and SDAW-CAS, 2.65-4.14). The correlation coefficients between age and SD velocity were: G. -0.78; W, -0.45; SDAW-CD, -0.68 and SDAW-CAS, -0.72 (P < 0.05 in all cases). As a rule, at each time point the gerbils presented high...Continue Reading

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