Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition

Analytical Cellular Pathology (Amsterdam)
Sellamuthu Subbanna GounderBaskar Subramani

Abstract

Age-associated changes in natural killer (NK) cell population, phenotype, and functions are directly attributed to the risk of several diseases and infections. It is predicted to be the major cause of the increase in mortality. Based on the surface density of CD56, NK cells are subdivided into two types, such as CD56bright and CD56dim cells, which represent cytokine production and cytotoxicity. In our study, we have examined the age-associated changes in the NK cell population and their subsets at different age groups of males and females (at a range from 41 to 80 years). We found that the total lymphocyte count significantly dropped upon aging in both genders. Although, the level of total immune cells also dropped on aging, and surprisingly the total NK cell population was remarkably increased with the majority of NK cells being CD56dim. Subsequently, we evaluated the proliferation potential of NK cells and our results showed that the NK cell proliferation ability declines with age. Overall, our findings prove that there is an increase in the circulating NK cell population upon aging. However, the proliferation rate upon aging declines when compared to the young age group (<41 yrs).

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Citations

Mar 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kun Kuk ShinJae Youl Cho
Apr 5, 2020·American Journal of Primatology·Matthias MietschBerit Roshani
Jun 24, 2020·International Journal of Molecular Sciences·Anthony M BattramBeatriz Martín-Antonio
Jul 25, 2020·Seminars in Immunopathology·Noémie GensousPaolo Garagnani
Mar 3, 2020·Frontiers in Cellular and Infection Microbiology·Sean J JudgeRobert J Canter
Jul 11, 2020·Biomedicines·Yegor E YegorovAlexander N Orekhov
Dec 29, 2020·Frontiers in Immunology·Banghao JianZhengqi Lu
Jan 12, 2021·Journal of Immunology Research·Xiaokang ZengQiang Xiao
Feb 4, 2021·Aging and Disease·Wanxue HeLixin Xie
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Carolina LliberosKarla J Hutt
Aug 8, 2021·Cancers·Tânia Fortes-AndradePaulo Rodrigues-Santos
Dec 17, 2021·Ageing Research Reviews·Bastian Robinson Baarz, Lothar Rink

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

CXP

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