Effect of aging on the substance P receptor, NK-1, in the spinal cord of rats with peripheral nerve injury

Somatosensory & Motor Research
W L CruceS L Stuesse

Abstract

Substance P (SP) levels in the spinal cords of very old rats are less than the levels in younger rats (Bergman et al., 1996). After injury to a peripheral nerve in young rats, immunoreactivity (ir) to the SP receptor, NK-1 (neurokinin-1), increases in the spinal cord ipsilateral to the injury and the increases are correlated with the development of thermal hyperalgesia (Goff et al., 1998). Thus we postulated that aged rats might display an increased sensitivity to thermal stimulation before peripheral nerve injury and that they might respond differently to injury than do younger rats. To test this hypothesis, we used the Bennett and Xie model (1988) of chronic constriction injury (CCI) to the sciatic nerve to induce a neuropathic pain condition. We investigated the effect of age on changes in NK-1 ir in superficial layers of the dorsal horn and on numbers of NK ir cells in deeper laminae at the L4-L5 levels of the spinal cord after CCI. NK-1 receptors were tagged immunohistochemically and their distribution quantified by use of computer-assisted image analysis. NK-1 ir changes were related to alterations in thermal and tactile sensitivity that developed after CCI in young, mature and aged (4-6, 14-16, and 24-26 months) Fischer ...Continue Reading

Citations

Apr 25, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Robert P Yezierski
Oct 22, 2002·Expert Opinion on Investigational Drugs·Robert Vink, Alan J Nimmo
Jan 5, 2002·Expert Opinion on Investigational Drugs·J KameiL F Tseng
Jan 24, 2006·European Journal of Pain : EJP·Gisèle PickeringAlain Eschalier
Feb 27, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R P YezierskiC J Vierck
Jun 26, 2004·The Clinical Journal of Pain·Stephen J Gibson, Michael Farrell

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