Effect of Agrimonia pilosa Ledeb Extract on the Antinociception and Mechanisms in Mouse.

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Soo-Hyun ParkHong-Won Suh

Abstract

In the present study, the antinociceptive profiles of Agrimonia pilosa Ledeb extract were examined in ICR mice. Agrimonia pilosa Ledeb extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Agrimonia pilosa Ledeb extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P (0.7 µg) was diminished by Agrimonia pilosa Ledeb extract. Intraperitoneal (i.p.) pretreatment with yohimbine (α(2)-adrenergic receptor antagonist) attenuated antinociceptive effect induced by Agrimonia pilosa Ledeb extract in the writhing test. However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by Agrimonia pilosa Ledeb extract in the writhing test. Our results suggest that Agrimonia pilosa Ledeb extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of Agrimonia pilosa Ledeb extract may be mediated by α(2)-adrenergic receptor, but not opioidergic and serotonergic receptors.

References

Feb 1, 1987·Japanese Journal of Pharmacology·K MiyamotoR Koshiura
May 1, 1985·Pain·C R ChapmanA E Reading
May 1, 1985·Japanese Journal of Pharmacology·R KoshiuraH Taguchi
Oct 17, 1980·European Journal of Pharmacology·J L Hylden, G L Wilcox
May 22, 2003·Life Sciences·Seong-Soo ChoiHong-Won Suh
Oct 13, 2004·Phytotherapy Research : PTR·Yaolan LiVincent E C Ooi
Oct 13, 2006·Bioscience, Biotechnology, and Biochemistry·Chang Hwa JungSeong-Gyu Ko
Apr 1, 1989·Planta medica·M YamakiS Takagi
May 3, 2007·Journal of Medicinal Food·R S TalhoukE K Barbour
Oct 21, 2009·Chemistry & Biodiversity·Liancai ZhuChao Zheng
Jan 9, 2010·Microbiology and Immunology·Woo-Jin ShinBaik-Lin Seong
Jan 22, 2010·Archives of Pharmacal Research·Soo-Hyun ParkHong-Won Suh
Feb 9, 2010·Immunological Investigations·Chang Hwa JungSeong-Gyu Ko
Jul 31, 2010·Immunology and Allergy Clinics of North America·Joohee Lee, Leonard Bielory
Sep 3, 2010·Phytochemistry·Hiroyoshi KatoKazuo Koike

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The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Soo-Hyun ParkHong-Won Suh
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