PMID: 30146637Aug 28, 2018Paper

Effect of akebiasaponin D with different concentrations on orthodontic tooth movement in rats

Shanghai kou qiang yi xue = Shanghai journal of stomatology
Jin-Jie CuiJun Zhang

Abstract

This study investigated the effect of local injection of akebiasaponin D (ASD) with different concentrations on the rate of orthodontic tooth movement in rats. Forty 6-week-old female Wistar rats were randomly divided into 4 groups with 10 rats in each group. Animal model for orthodontic tooth movement was established. The upper first molars of the rats were moved mesially by coil springs(force=40 g). ASD solution at the concentration of 5 mg/kg was locally injected in ASD1 group, and ASD solution at the concentration of 10 mg/kg was locally injected in ASD2 group. The rats of group PGE2 were injected PGE2 solution at the concentration of 25 μg/kg. The same amount of normal saline was injected in the control group. The rats were sacrificed in batch on the 3rd, 7th, 14th, 21st and 28th days after orthodontic treatment. The distance between upper first molar and second molar was measured. H-E straining was performed to observe the changes of periodontal tissue and the amount of osteoclast. SPSS13.0 software package was used for statistical analysis. The distance between the first and second molar was successively increased compared with the control group. On day 3, there was significant difference between PGE2 group and the contr...Continue Reading

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