Effect of alaptide, its analogues and oxiracetam on memory for an elevated plus-maze in mice

European Journal of Pharmacology
Zdenek HlinákE Kasafírek

Abstract

In the present study, the elevated plus-maze was used to evaluate memory in female mice. In Experiment 1, the mice retested on day 1, 4 or 7 after the initial session escaped from the open arm into the enclosed arm in a significantly shorter time than those retested on day 10 or 14. Thus, a 10-day inter-session interval was chosen for testing drugs which were expected to enhance memory. In Experiment 2, in the retest performed on day 10, both alaptide (cyclo(L-alanyl-1-amino-1- cyclopentanecarbonyl)) and oxiracetam, given immediately after the 1st session, reduced the transfer latency from the open arm into the enclosed arm as compared with that of the controls. In Experiment 3, a similar effect, i.e., the retention of spatial information, was facilitated by post-session injections of 5 out of 21 alaptide analogues. The new compounds represent the 2,5-piperazinedione derivatives which contain 1-amino-1-cyclo-alkanecarboxylic acid (C3 to C7 ring). The cyclopentane- and cyclohexane-ring was substituted by an alkyl group. In the series with the cycloalkane ring, the importance of the structure of alaptide was confirmed again, which underlines the importance of the cyclopentane ring; the active structures had L-alanine instead of g...Continue Reading

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Citations

Dec 2, 2000·Behavioural Brain Research·Z Hlinák, I Krejcí
Feb 15, 2002·Behavioural Brain Research·Zdenek Hlinák, Ivan Krejcí
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Jan RohlíčekBohumil Kratochvíl
Jun 10, 2016·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Wusan WangHaitang Xie
Aug 3, 2010·Journal of Pharmaceutical and Biomedical Analysis·Ondrej JulínekMarie Urbanová

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