Effect of alaptide, its analogues and oxiracetam on memory for an elevated plus-maze in mice

European Journal of Pharmacology
Zdenek HlinákE Kasafírek

Abstract

In the present study, the elevated plus-maze was used to evaluate memory in female mice. In Experiment 1, the mice retested on day 1, 4 or 7 after the initial session escaped from the open arm into the enclosed arm in a significantly shorter time than those retested on day 10 or 14. Thus, a 10-day inter-session interval was chosen for testing drugs which were expected to enhance memory. In Experiment 2, in the retest performed on day 10, both alaptide (cyclo(L-alanyl-1-amino-1- cyclopentanecarbonyl)) and oxiracetam, given immediately after the 1st session, reduced the transfer latency from the open arm into the enclosed arm as compared with that of the controls. In Experiment 3, a similar effect, i.e., the retention of spatial information, was facilitated by post-session injections of 5 out of 21 alaptide analogues. The new compounds represent the 2,5-piperazinedione derivatives which contain 1-amino-1-cyclo-alkanecarboxylic acid (C3 to C7 ring). The cyclopentane- and cyclohexane-ring was substituted by an alkyl group. In the series with the cycloalkane ring, the importance of the structure of alaptide was confirmed again, which underlines the importance of the cyclopentane ring; the active structures had L-alanine instead of g...Continue Reading

References

Aug 15, 1975·Biochemical Pharmacology·D DE WIEDH M Greven
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R WalterD DE WIED
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R WalterL B Flexner
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·L Merlini, M Pinza
Jan 1, 1987·Psychopharmacology·R DantzerM Le Moal
Jan 1, 1987·Psychopharmacology·R G Lister
Apr 29, 1993·Regulatory Peptides·R Dantzer, R M Bluthé
Apr 1, 1992·Behavioural Pharmacology·Zdenek Hlinák, Ivan Krejcí

Citations

Dec 2, 2000·Behavioural Brain Research·Zdenek Hlinák, Ivan Krejcí
Feb 15, 2002·Behavioural Brain Research·Zdenek Hlinák, Ivan Krejcí
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Jan RohlíčekBohumil Kratochvíl
Jun 10, 2016·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Wusan WangHaitang Xie
Aug 3, 2010·Journal of Pharmaceutical and Biomedical Analysis·Ondrej JulínekMarie Urbanová

Related Concepts

Oxiracetam
Cyclo(alanine-(1-amino-1-cyclopentane)carbonyl)
Metazoa
Memory
Neuropeptides
Cyclic Peptides
Piperazines
Psychotropic Drugs
Pyrrolidines
Structure-Activity Relationship

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Incretins

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.