PMID: 11903744Mar 21, 2002Paper

Effect of alcohol withdrawal on liver transaminase levels and markers of liver fibrosis

Journal of Gastroenterology and Hepatology
S CampbellB J Danesh

Abstract

Acute alcohol withdrawal causes changes in hepatic blood flow and metabolism that may result in liver damage. This study aims to assess liver function tests and markers of hepatic fibrogenesis following alcohol withdrawal in alcoholics with clinically compensated liver disease. Serial liver function tests and clinical assessments were performed on 22 male alcoholics during alcohol withdrawal. Plasma tissue inhibitor of metalloproteinase 1 (TIMP1), an inhibitor of collagen degradation, and plasma amino-terminal procollagen III peptide (PIIINP), a collagen precursor molecule, were measured in these alcoholics and in 11 control subjects. Transaminase levels did not change significantly over 7 days when all subjects were analyzed together. However, 32% of subjects showed a marked transaminase rise. These subjects did not differ from the others in baseline characteristics or short-term outcome, but had a greater benzodiazepine requirement. Only one subject consumed paracetamol (acetaminophen; 1-2 g/day). He had the largest transaminase rise. By comparing PIIINP assays, intact PIIINP concentration appears to increase following alcohol withdrawal. The TIMP1 levels were elevated in alcoholic subjects, but did not change following withd...Continue Reading

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Citations

Apr 9, 2008·World Journal of Gastroenterology : WJG·Satoshi MamoriHisao Tajiri
Oct 10, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Roberto CatanzaroFrancesco Marotta
Nov 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Samir Zakhari, Ting-Kai Li
May 10, 2020·Indian Journal of Psychiatry·Shanti Mohan KethawathSiddharth Sarkar

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