PMID: 11900276Mar 20, 2002Paper

Effect of aldose reductase inhibition on interleukin-1beta-induced nitric oxide (NO) synthesis in vascular tissue

International Journal of Experimental Diabetes Research
Juan MoralesJeffrey L Ram

Abstract

Glucose metabolism via sorbitol pathway has been implicated as a possible contributor to the diabetes-related vascular changes. Nitric oxide plays a major regulatory role in the vascular dilatatory and constricted response. Also it has been observed that diabetes causes vascular changes leading to a decrease in nitric oxide production. Additionally the accumulation of sorbitol is also related to decreased nitric oxide production. In the present study we investigated the effect of normal and high glucose in the presence or absence of both interleukin-1beta or an aldose reductase inhibitor on nitric oxide production in rat aortic rings in vitro. Aortic rings from normal male Wistar rats were dissected and incubated for 24 to 48 hrs in the presence of glucose (5.0 mM or 20 mM) or with or without interleukin (20 ng/ml). Other rings were incubated in the above media with the addition of the aldose reductase inhibitor (WAY 121509). Interleukin-1beta stimulated the 24 hr nitric oxide production and WAY 121509 decreased it under both low and high glucose culture conditions. The interleukin-1beta stimulation was continued for 72 hrs. Nitric oxide production in response to interleukin-1beta was greater at all time points when compared to...Continue Reading

Citations

Sep 21, 2004·The British Journal of Ophthalmology·R A Kowluru, S Odenbach
Feb 28, 2008·Journal of Hypertension·Nuria LafuenteCarlos F Sánchez-Ferrer

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