Effect of alendronate on HIV-associated osteoporosis: a randomized, double-blind, placebo-controlled, 96-week trial (ANRS 120)

AIDS Research and Human Retroviruses
Sylvie RozenbergANRS 120 Fosivir Study Group

Abstract

Low bone mineral density (BMD) is common in HIV-infected patients. Bisphosphonates such as alendronate potently inhibit bone resorption and are effective against osteoporosis. The aim of the ANRS 120 Fosivir trial was to evaluate the effect of alendronate on low BMD in HIV-infected patients. HIV-1-infected adults with a t-score≤-2.5 at the lumbar spine and/or total hip, as assessed by dual x-ray absorptiometry, and no other known risk factors for low BMD, were randomized to receive either extended-release alendronate 70 mg weekly or placebo for 96 weeks, with stratification for gender. All the patients also received daily calcium carbonate (500 mg) and vitamin D (400 U). The primary endpoint for efficacy was the percentage change in BMD at the site with a t-score≤-2.5. Forty-four antiretroviral-treated patients (42 men, 2 women) were enrolled. The median age was 45 years, the median CD4 cell count was 422/mm(3), and viral load was <400 copies/ml in 84% of patients. Baseline characteristics were well balanced between the alendronate (n=20) and placebo (n=24) groups. At baseline, 15 patients (75%) in the alendronate group and 17 patients (71%) in the placebo group had a t-score≤-2.5 at the lumbar spine. In the main analysis, BMD ...Continue Reading

References

Sep 9, 2000·The New England Journal of Medicine·E OrwollA Lombardi
Nov 30, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S KoltaC Roux
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C AmielM C De Vernejoul
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·E Michael LewieckiUNKNOWN International Society for Clinical Densitometry
Aug 12, 2004·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·K G Faulkner
Nov 25, 2004·HIV Clinical Trials·G GuaraldiR Esposito
Mar 15, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kristin MondyPablo Tebas
Dec 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Valerianna Amorosa, Pablo Tebas
Mar 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael T Yin, Marshall J Glesby
Dec 16, 2006·BMJ : British Medical Journal·Kenneth E S Poole, Juliet E Compston
Aug 1, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J PriorS Walmsley
Oct 11, 2007·The Journal of Clinical Endocrinology and Metabolism·Mark J BollandIan R Reid
Jan 16, 2008·AIDS·Charles CazanaveUNKNOWN Groupe d'Epidémiologie Clinique du SIDA en Aquitaine
Jul 3, 2008·The Journal of Clinical Endocrinology and Metabolism·Virginia A TriantSteven K Grinspoon
Feb 21, 2009·The American Journal of Medicine·John P Bilezikian
Mar 2, 2011·PloS One·Julie A WomackUNKNOWN Veterans Aging Cohort Study Project Team
Mar 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin YoungUNKNOWN HIV Outpatient Study (HOPS) Investigators

❮ Previous
Next ❯

Citations

Apr 25, 2012·Current HIV/AIDS Reports·Aoife G Cotter, Patrick W G Mallon
Jul 3, 2013·Clinical Interventions in Aging·Lauren J GleasonKrupa Shah
Jul 30, 2014·Current HIV/AIDS Reports·Amy H WarrinerE Turner Overton
Jun 12, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S FerrariUNKNOWN IOF Committee of Scientific Advisors Working Group on Osteoporosis Pathophysiology
Aug 30, 2014·Endocrinology and Metabolism Clinics of North America·Juliet Compston
Nov 30, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Raquel SorianoAdolfo Diez-Perez
Jul 24, 2012·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Murielle Mary-KrauseSylvie Rozenberg
Apr 5, 2013·Pharmacotherapy·Jason J SchaferKathleen E Squires
Apr 16, 2014·The Lancet. Diabetes & Endocrinology·Mark J BollandIan R Reid
Jun 9, 2016·Journal of Internal Medicine·J Compston
Feb 19, 2016·Current Opinion in HIV and AIDS·Eugenia Negredo, Amy H Warriner
Apr 18, 2017·Current Treatment Options in Infectious Diseases·Caitlin A MoranIghovwerha Ofotokun
May 27, 2020·The Journal of Clinical Endocrinology and Metabolism·Jessica PepeSerge Ferrari
Jan 27, 2016·Expert Opinion on Pharmacotherapy·E NegredoB Clotet
Jan 23, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Todd T BrownWilliam G Powderly
May 2, 2018·Current HIV/AIDS Reports·Evelyn Hsieh, Michael T Yin
Oct 5, 2018·JBMR Plus·Melissa O Premaor, Juliet E Compston
Feb 25, 2015·BoneKEy Reports·Juliet Compston

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT00120757

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Benjamin YoungHIV Outpatient Study (HOPS) Investigators
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Grace A McComseyTodd T Brown
Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
Murielle Mary-KrauseSylvie Rozenberg
© 2022 Meta ULC. All rights reserved