Effect of alendronate on the mandible and long bones: an experimental study in vivo

Pediatric Research
Sharon R OyhanartPatricia Mónica Mandalunis

Abstract

Bisphosphonates are anticatabolic agents that inhibit bone resorption and are widely used to treat osteoporosis and bone metastases in adults. They are also used in young patients with diseases like osteogenesis imperfecta or juvenile osteoporosis. Bone modeling/remodeling is elevated in growing subjects, and inhibition of osteoclastic activity has been shown to interfere with growth. Thus, our objective was to evaluate the effect of alendronate (ALN) on growing animals. Healthy male Wistar rats, aged 1 mo, received ALN or vehicle for 8 wk. Serum levels (calcemia, phosphatemia, and total alkaline phosphatase) were determined. Morphometric (rat: femur and tibia weight and length and hemimandible growth) and histomorphometric parameters (thickness of tibial epiphyseal cartilage and each cartilage zone, interradicular bone volume in the first lower molar, trabeculae volume, percentage of bone and cartilage, and osteoclast number in mandibular condyles) were assessed. ALN caused a significant decrease in femur and tibia length, tibial cartilage thickness, and longitudinal growth of hemimandibles. It increased interradicular bone volume and mandibular condyle trabeculae volume, increasing the percentage of cartilage and osteoclast n...Continue Reading

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Citations

Oct 10, 2015·Developmental Biology·Erin L EalbaRichard A Schneider
Oct 25, 2017·Journal of Cellular and Molecular Medicine·Emi OkadaShinji Kuroda
Nov 7, 2019·Oral and Maxillofacial Surgery·Stephanie Joana Roman MartelliAna Carolina Uchoa Vasconcelos
Aug 11, 2021·Advances in Rheumatology·Renato Vicente FerreiraVera Lucia Szejnfeld

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