PMID: 8985093Jan 6, 1997Paper

Effect of all trans-retinoic acid (ATRA) on the adhesive and motility properties of acute promyelocytic leukemia cells

International Journal of Cancer. Journal International Du Cancer
G TarabolettiA Rambaldi

Abstract

All trans-retinoic acid (ATRA) induces complete remission in acute-promyelocytic-leukemia (APL) patients. This study investigated the adhesive properties of APL cells for the endothelium and the extracellular matrix, their motility and the effect of ATRA on these functions. Blasts from 7 APL patients adhered to resting and IL-1-activated endothelium, to the same degree as normal PMN. Adhesion was partially mediated by ICAM-1 and, for IL-1-activated endothelium, by VCAM-1 and E-selectin. These cells showed less adhesiveness for the matrix than PMN, although they maintained the same substrate preference: they adhered to fibronectin and thrombospondin, but not to laminin and type-IV collagen. Exposure to ATRA in vitro (1 microM for 48 to 96 hr) increased the adhesiveness of APL cells; this effect was particularly evident in the case of sub-endothelial matrix and fibronectin. A similar increment in adhesiveness was observed when comparing cells from 2 patients before and after treatment with ATRA. APL cells migrated in response to fMLP and motility was increased by ATRA. In conclusion, APL cells were less adhesive to the matrix than PMN, but treatment with ATRA considerably enhanced their adhesive properties. This could be importan...Continue Reading

References

Mar 1, 1992·Immunology Today·G A ZimmermanT M McIntyre
Aug 1, 1992·Leukemia Research·R OfirY Weinstein
Aug 25, 1992·Annals of Internal Medicine·S R FrankelR P Warrell
Dec 1, 1990·The Journal of Cell Biology·P J MansfieldS J Suchard
Jan 1, 1993·Annual Review of Immunology·M P Bevilacqua
Jul 15, 1993·The New England Journal of Medicine·R P WarrellL Degos

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Citations

Apr 26, 2005·American Journal of Hematology·Yavuz BeyazitHakan Goker
Dec 17, 2008·Annals of the New York Academy of Sciences·Karina Pino-LagosRandolph J Noelle
Aug 26, 2010·British Journal of Haematology·Maaike Luesink, Joop H Jansen
May 20, 1998·International Journal of Cancer. Journal International Du Cancer·P MatarreseW Malorni
Jul 10, 2001·British Journal of Haematology·S MustjokiA Vaheri
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephanie DarmaninMasanobu Kobayashi
Jul 13, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L H CamachoR P Warrell

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