Effect of allium cepa-allantoin-pentaglycan gel on skin hypertrophic scars: clinical and video-capillaroscopic results of an open-label, controlled, nonrandomized clinical trial

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
A CampanatiAnnamaria Offidani

Abstract

Hypertrophic scar formation is a process in which prolonged angiogenesis sustained by vascular endothelial growth factor cutaneous expression plays an important role. This in vivo study was conducted to evaluate the clinical effect of a topical gel containing onion extract, allantoin, and pentaglycan on hypertrophic scars and keloids. Thirty people with hypertrophic scars or keloids were examined. Fifteen patients received a topical application of a gel containing allium cepa, allantoin, and pentaglycan twice a day for 24 weeks, the remaining 15 patients received no topical treatments. A clinical evaluation and an intravital videocapillaroscopy were performed on every patient at baseline (T0) and 24 weeks (T24) after the treatment. Only the patients who received the topical treatment showed a significant reduction in neoangiogenetic features, demonstrated through an improvement of erythema and all videocapillaroscopic markers of neoangiogenesis. These changes induced by therapy led to a general improvement of the lesions. Topical applications of a gel containing allium cepa, pentaglycan, and allantoin twice a day for 24 weeks seems to be useful in reducing neoangiogenesis in hypertrophic scars and keloids, resulting in clinical...Continue Reading

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Citations

Nov 19, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Thuzar M Shin, Jeremy S Bordeaux
Aug 23, 2011·Facial Plastic Surgery Clinics of North America·Chong Wee Foo, Payam Tristani-Firouzi
Oct 5, 2015·Burns : Journal of the International Society for Burn Injuries·Kyomi MiharaNorito Katoh
Aug 14, 2013·Expert Opinion on Pharmacotherapy·Chenyu Huang, Rei Ogawa
Mar 31, 2015·Neuromuscular Disorders : NMD·A CampanatiA Offidani
Aug 31, 2016·Burns and Trauma·Kwang Chear LeeNaiem Moiemen
Jul 28, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·I BobyrA Offidani
Aug 30, 2019·Phytotherapy Research : PTR·Yahya AsemaniZahra Amirghofran
Aug 25, 2016·Plastic and Reconstructive Surgery·Ibrahim KhansaJeffrey E Janis
Jul 16, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·G V OliveiraD M Hexsel

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