PMID: 9160417Jan 1, 1997Paper

Effect of allopurinol on the formation of reactive oxygen species during intense exercise in the horse

Research in Veterinary Science
P C MillsP Harris

Abstract

Allopurinol was administered to six horses in a cross-over study to determine the relative contribution of xanthine oxidase (XO) activity to the formation of reactive oxygen species (ROS) in the horse during intense exercise. Exercise increased the mean (SEM) plasma lipid hydroperioxide concentration to a maximum of 492.7 (33.4) microM within one minute of exercise completion and maximum levels of both oxidised glutathione (GSSG) in haemolysates of red blood cells and the glutathione redox ratio (GRR) occurred 20 minutes after exercise (87.2 [12.2] microM and 8.9 [0.9] per cent, respectively). Allopurinol significantly reduced lipid hydroperoxides, GSSG and the GRR at the corresponding maximal times after exercise measured during control exercise (217.5 [32.1] microM. 63.8 [8.6] microM and 6.8 [0.7] per cent, respectively). Significantly higher levels of hypoxanthine and xanthine were measured after exercise in the plasma of horses that received allopurinol than in control horses, although uric acid levels remained constant. In control horses, plasma uric acid concentrations increased after exercise to a maximum 20 minutes after exercise of 28.1 (2.6) microM, significantly higher than in horses given allopurinol (9.6 [1.3] micr...Continue Reading

References

Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·R C HarrisR A Harkness
Oct 1, 1990·Archives of Biochemistry and Biophysics·G G DuthieP C Morrice
May 1, 1993·The Journal of Surgical Research·K KoikeA Banerjee
Jan 1, 1993·Critical Reviews in Toxicology·J P Kehrer
Dec 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·P C MillsN C Smith

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Citations

Dec 18, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Aristidis S VeskoukisDimitrios Kouretas
Mar 24, 2007·The Veterinary Clinics of North America. Equine Practice·Carl Soffler
Jan 9, 2007·Behavioural Brain Research·Peter G Osborne, Masaaki Hashimoto
Feb 18, 2006·Free Radical Research·Nathalie KirschvinkPascal Gustin
Apr 7, 2012·Journal of the International Society of Sports Nutrition·Christiano Rr AlvesBruno Gualano
Dec 22, 1999·The American Journal of Physiology·L M HeunksP N Dekhuijzen

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