Effect of allyl isothiocyanate on NF-κB signaling in 7,12-dimethylbenz(a)anthracene and N-methyl-N-nitrosourea-induced mammary carcinogenesis

Breast Cancer : the Journal of the Japanese Breast Cancer Society
Thangarasu RajakumarKrishnaswamy Gunasekaran

Abstract

Inflammation plays a pivotal role in the process of carcinogenesis and phytochemicals have anti-inflammatory properties gaining more importance in cancer chemoprevention. The present study aimed to investigate the anti-inflammatory effect of allyl isothiocyanate (AITC) on 7,12-dimethylbenz(a)anthracene (DMBA)- and N-methyl-N-nitrosourea (MNU)-induced mammary carcinogenesis in female Sprague-Dawley rats. RT-PCR and western blot analysis showed that inflammatory markers such as NF-κB p65, TNF-α, and IL-6 were overexpressed in mammary tumor tissues. Histological analysis of tumor tissues shows abnormality in hematoxylin and eosin (H&E) staining and toluidine blue (TB) staining of mast cell content, and lipid accumulation in oil red O staining. Administration of AITC (20 mg/kg bw) to carcinogen-injected rats significantly decreased the expression of NF-κB p65, TNF-α, and IL-6 in mammary tissues. Further, molecular docking study demonstrates the binding of AITC to NF-κB p65. Remarkably, AITC treatments control the growth of cancer cells as clearly evidenced by histopathological analysis. Staining of mammary tissues for mast cells and lipids indicates that AITC treatment to carcinogen-administrated rats significantly reduced mammary ...Continue Reading

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Citations

Jan 5, 2018·International Journal of Molecular Sciences·Md Abu SayeedLory Santarelli
Jan 12, 2020·Journal of Biochemical and Molecular Toxicology·Rajendran JayaganeshRaju Murali
Dec 17, 2020·International Journal of Molecular Sciences·Paula García-IbañezPilar García-Peñarrubia
Oct 13, 2021·Toxicology Mechanisms and Methods·Shaimaa Waz, Asmaa I Matouk

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