Effect of almitrine administration on pulmonary arterial pressure in resting and exercising dogs

Respiration Physiology
R J FavierR Flandrois

Abstract

In addition to its well-known ventilatory effect, a small rise in pulmonary arterial pressure or pulmonary vascular resistance is occasionally observed with chronic administration of almitrine. In order to test the hypothesis of enhancement of exercise pulmonary vasoconstriction by almitrine, mongrel dogs were studied at rest and during submaximal exercise before and after 4 weeks of chronic ingestion of almitrine (10 mg/kg). It was shown that resting pulmonary arterial pressure (PAP) remained unchanged by almitrine treatment. However, when exercise was superimposed on almitrine medication, PAP was significantly increased throughout the exercise bout. Thus, the rise in PAP during the 20th min of exercise averaged 8.7 +/- 3.4 mm Hg after almitrine treatment while PAP increased by only 1.3 +/- 1.7 mm Hg before medication. The exaggerated exercise-induced PAP response in conjunction with the enhanced secretion of norepinephrine that we observed during almitrine treatment suggests that catecholamine could be involved in the pulmonary haemodynamic adjustments. Furthermore, mixed-venous PO2 (PvO2) both during rest and exercise declined with the prolongation of almitrine ingestion, suggesting that PvO2 might possibly be implicated in ...Continue Reading

References

Apr 1, 1976·Circulation Research·A P Fishman
Nov 1, 1988·Respiration Physiology·S NakanishiY Nishimoto
Jan 1, 1989·The American Review of Respiratory Disease·C MélotP Mols
Aug 1, 1985·Respiration Physiology·R J FavierR Flandrois
Sep 1, 1967·The Journal of Physiology·A G CampbellJ E Milligan
Jan 1, 1980·Annual Review of Physiology·E H Bergofsky

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Citations

Mar 15, 2015·The Veterinary Clinics of North America. Equine Practice·Stacey Sullivan, Kenneth Hinchcliff

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