Effect of alpha-adrenoceptor agents on imipramine-induced antinociception in nerve-ligated mice

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
M Sahebgharani, M R Zarrindast

Abstract

In this study, the effects of adrenoceptor agonists and antagonists on antinociception induced by imipramine in sciatic-nerve-ligated mice were investigated. The response of different doses of morphine, imipramine and adrenoceptor agonists and antagonists was examined 14 days after unilateral nerve-ligation in the hot-plate test. Intraperitoneal injection of different doses of morphine (3, 6 and 9 mg/kg), imipramine (10, 20 and 40 mg/kg), the alpha(2)-adrenoceptor agonist, clonidine (0.05, 0.1 and 0.2 mg/kg) or the alpha(1)-adrenoceptor agonist, phenylephrine (2, 4 and 8 mg/kg) induced dose-related antinociception in both intact and nerve-ligated mice. The antinociception induced by morphine but not that of imipramine, clonidine or phenylephrine, in nerve-ligated mice was significantly less than that induced in intact animals. Imipramine in combination with clonidine tends to induce a higher response, but the combination of imipramine with phenylephrine did not lead to significant potentiation. The alpha(2)-adrenoceptor antagonist, yohimbine, reduced the response induced by imipramine or imipramine plus clonidine in intact and nerve-ligated animals. However, the alpha(1)-adrenoceptor antagonist, prazosin, did not alter imiprami...Continue Reading

References

May 7, 1992·The New England Journal of Medicine·M B MaxR Dubner
May 1, 1985·Pharmacology, Biochemistry, and Behavior·T L Yaksh
Jan 1, 1989·Pain·M L VargasM M Puig
Apr 1, 1994·Pain·S CanaveroV Bonicalzi
Jun 1, 1996·Journal of Pain and Symptom Management·M D Bedder

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Citations

May 30, 2002·Progress in Neurobiology·Mark J Millan
Oct 25, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kiyomi Matsuzawa-YanagidaTsutomu Suzuki
Jul 25, 2006·The International Journal of Neuroscience·Mousa SahebgharaniM R Zarrindast
Jun 29, 2002·Anesthesia and Analgesia·Fumiko YokogawaAkiyoshi Hosoyamada

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