PMID: 5061Apr 1, 1976

Effect of alpha and beta adrenergic blockade on epinephrine induced pulmonary insufficiency

Annals of Surgery
J L BerkR Koo


Recent studies demonstrated that epinephrine causes significant pulmonary A-V shunting. This study reports the effect of alpha and beta adrenergic blockade on this shunting. Sixty-three anesthetized mongrel dogs were ventilated with a mechanical respirator. Measurements of (1) the pulmonary shunt, (2) cardiac output, (3) mean pulmonary artery, pulmonary capillary wedge and systemic pressures, and (4) pulmonary and systemic vascular resistances were obtained at 5, 15 and 30 minute intervals during the first hour and hourly for 5 hours. Fifteen dogs received no treatment. All others received epinephrine hydrochloride, 2 mug/kg/min for 5 hours. Ten received epinephrine only. Ten were pretreated with propranolol hydrochloride, 250 mug/kg, 12 with phenoxybenzamine, 1 mg/kg, and 16 with phenoxybenzamine and propranolol. Propranolol significantly decreased the epinephrine induced pulmonary shunt at all times and was the most effective drug. Phenoxybenzamine decreased the early shunting, but less than propranolol, and did not decrease the late shunting. Blockade with propranolol and phenoxybenzamine was less effective than propranolol alone. Based on the observed hemodynamic changes it was suggested that beta blockade is effective in r...Continue Reading


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Feb 1, 1967·Surgery, Gynecology & Obstetrics·J L BerkR Niazmand
Aug 1, 1963·Circulation Research·D E LEHRA P FISHMAN
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Related Concepts

Adrenergic alpha-Antagonists
Adrenergic beta-Antagonists
Diastolic Blood Pressure
Blood Capillaries
Carbon Dioxide
Cardiac Output
Canis familiaris
Phenoxybenzamine Hydrochloride

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