PMID: 8971923Jan 1, 1996Paper

Effect of alpha-MSH upon cyclic AMP levels induced by the glutamatergic agonists NMDA, quisqualic acid, and kainic acid

Peptides
S R de Barioglio, M I Brito

Abstract

This study was carried out to investigate possible interactions between some glutamatergic agonists and the peptide alpha-MSH upon the cyclic AMP levels. We used an in vitro tissue slice preparation incubated in the presence of different glutamatergic agonists such as N-methyl-D-aspartic acid (NMDA), quisqualic acid (QUIS), kainic acid (KA), and the peptide alpha-MSH together with each agonist. Slices containing caudate putamen and accumbens were chosen according to neurochemical data indicating that the striatum contains a moderate amount of MSH binding sites and also receives glutamatergic innervation. Exposure of these slices to either MSH or to the agonists NMDA or QUIS resulted in an increase in the cAMP levels in relation to controls. Nevertheless, incubation with KA resulted in no changes in the nucleotide levels. The combination of MSH/NMDA induced a reduction of cAMP levels in relation to those obtained with NMDA alone. The combinations of QUIS/MSH or KA/MSH also induced variations in the values of nucleotide in relation to the those obtained with the peptide alone or with the corresponding agonist; these changes were related to the dose of agonist used in each case. The results obtained in these experiments suggest th...Continue Reading

References

Oct 1, 1992·Trends in Biochemical Sciences·E A Barnard
May 25, 1991·European Journal of Pharmacology·W J FlorijnD H Versteeg
Jul 1, 1990·Trends in Neurosciences·A M Graybiel
Dec 7, 1989·European Journal of Pharmacology·P PopoliA Scotti de Carolis
Jan 1, 1986·Advances in Experimental Medicine and Biology·J Hyttel, J Arnt
Dec 1, 1985·Biochemical Society Transactions·P G StrangeS Worrall
Jan 1, 1993·Trends in Pharmacological Sciences·D D Schoepp, P J Conn
May 1, 1994·The Journal of Comparative Neurology·D G StandaertJ B Penney
Dec 20, 1993·Annals of the New York Academy of Sciences·M MasuS Nakanashi

❮ Previous
Next ❯

Citations

Apr 18, 2016·International Journal of Medical Microbiology : IJMM·Jean Henrique de Silva RodriguesMichael Duszenko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.