Twenty patients with extrinsic type bronchial asthma are shown to have a significant fall in vital capacity (V.C.) and forced expiratory volume in 1 second (F.E.V.(1)) after an intravenous infusion of 50mug. of histamine dihydrochloride. In 10 of these subjects the fall in V.C. and F.E.V.(1) produced by intravenous histamine is inhibited by the alpha-receptor blocking drugs phentolamine and phenoxybenzamine injected before the histamine test. The inhalation of disodium cromoglycate in 10 subjects is also shown to inhibit the fall in V.C. and F.E.V.(1) produced by the intravenous infusion of histamine. It is suggested that bronchial smooth muscle in asthmatic subjects has alpha-adrenergic receptor sites, and that a possible mechanism for the action of disodium cromoglycate is that it stabilizes the cell membrane, thereby altering calcium ion transport.
Disodium cromoglycate (FPL 670) ('Intal'): a specific inhibitor of reaginic antibody-antigen mechanisms
A protective action of disodium cromoglycate against the contraction of guinea-pig ileum induced by various pharmacological stimulants
The place of cromolyn (lomudal, intal, aarane) in the management of bronchial asthma (author's transl)
Drug-induced changes in capillary filtration coefficient and blood flow in the innervated small intestine of the anaesthetized cat
Exercise-induced bronchoconstriction as an expression of bronchial hyperreactivity: a study of its mechanisms in children
Effect of antihistamines and antiallergic drugs on responses to allergen and histamine provocation tests in asthma
Influence of circulating alpha adrenoceptor agonists on lung function in patients with exercise induced asthma and healthy subjects
The effects of topical sodium cromoglicate on itch and flare in human skin induced by intradermal histamine: a randomised double-blind vehicle controlled intra-subject design trial
Effect of long-term treatment with sodium cromoglycate on nonspecific bronchial hyperresponsiveness in asthma
The effect of an alpha-adrenergic receptor blocking drug on histamine sensitivity in bronchial asthma
Histamine and allergen induced changes in nasal airways resistance measured by anterior rhinomanometry: reproducibility of the technique and the effect of topically administered antihistaminic and anti-allergic drugs
The action of prazosin and propylene glycol on methoxamine-induced bronchoconstriction in asthmatic subjects
Bronchial hyperreactivity after treatment with sodium cromoglycate in atopic asthmatic patients not exposed to relevant allergens
Effect of alpha receptor blocking drug, thymoxamine, on allergen induced bronchoconstriction in extrinsic asthma
The airways response to phenylephrine after blockade of alpha and beta receptors in extrinsic bronchial asthma
The relationship of leucocyte adenyl cyclase activity and airways response to beta blockade and allergen challenge in extrinsic asthma
Long-term modification on histamine-induced bronchoconstriction by disodium cromoglycate and ketotifen versus placebo
Bronchial reactivity to inhaled histamine in asthmatic patients, before and after administration of atropine, phentolamine or disodium cromoglycate
Dual modes of action for disodium cromoglycate in inhibition of antigen-induced contractions of guinea-pig isolated airways smooth muscle
Effect of an alpha 2-adrenoceptor antagonist, midaglizole, on bronchial responsiveness to histamine in patients with mild asthma
Allergy and Asthma
Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.
Allergies & Environmental Factors
Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.
Adrenergic Receptors: Trafficking
Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.
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