Effect of altered iron metabolism on markers of haem biosynthesis and intestinal iron absorption in mice

Annals of Hematology
Abas H LaftahT J Peters

Abstract

In this study, well-characterised animal models of altered iron metabolism were used to investigate link(s) between haem biosynthesis and intestinal iron absorption. Mice rendered iron deficient by feeding a low-iron diet for 3-4 weeks showed low levels of hepatic non-haem iron and hepcidin mRNA, with reduced urinary 5-aminolaevulinic acid (ALA) excretion and enhanced intestinal iron absorption. Hepatic ALA synthase activity was reduced while ALA dehydratase activity was increased. Iron-loaded mice had markedly increased liver non-haem iron and hepcidin mRNA, with increased urinary ALA excretion. Intestinal iron absorption was decreased mainly due to a reduction in transfer of absorbed iron from mucosa to the carcass. Hepatic ALA synthase activity was increased and ALA dehydratase activity moderately reduced. Mice exposed to hypoxia (0.5 atm) for 1-3 days had reduced hepatic hepcidin mRNA and urinary ALA excretion, while intestinal iron absorption was increased. Hepatic ALA synthase activity was reduced. The ALA dehydratase activity in liver and spleen was markedly enhanced. Injection of ALA to iron-deficient mice or hypoxic mice reduced their intestinal iron absorption to normal levels. This study further supports the hypothes...Continue Reading

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Citations

Sep 11, 2008·The British Journal of Nutrition·Abas H LaftahAndrew T McKie
Dec 28, 2010·Free Radical Biology & Medicine·Nikolai L Chepelev, William G Willmore
Sep 22, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Lin LiChristian Holscher
Dec 15, 2005·British Journal of Haematology·Kishor B RajaRobert J Simpson
Apr 26, 2006·European Journal of Clinical Investigation·R Deicher, W H Hörl
Dec 14, 2011·Nutrition Research·Jayong ChungSung Nim Han
Feb 7, 2006·Biochimica Et Biophysica Acta·Gladys O Latunde-DadaRobert J Simpson
Aug 17, 2012·The Journal of Biological Chemistry·Yusuke YoshiokaTakashi Kato

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